Natural product anticipation through synthesis.
Natural product anticipation through synthesis.
复制标题
天然产物的合成预测。
DOI：
10.1038/s41570-021-00345-7
复制
发表时间：
2022-03
影响因子：
36.3
通讯作者：
Lawrence, Andrew L.
中科院分区：
文献类型：
--
作者：
Hetzler, Belinda E.;Trauner, Dirk;Lawrence, Andrew L.
天然产物合成仍然是化学中最具活力和智力回报的领域之一，尽管追求它的理由随着时间的推移而演变。在早期，重点是通过合成来阐明和确认结构，例如对可卡因、吗啡、士的宁和叶绿素的著名研究。在这之后的一个阶段，高度复杂的分子可以在实验室中以合理的方式被重建，这足以证明合成的经济成本和智力痛苦是合理的。从那时起，天然产物的合成就成为展示优雅策略的平台，用于“在飞行中”发明新方法，或证明用更简单的分子建立的方法的实用性和范围。现在我们添加了另一个我们觉得很吸引人的方面，即“天然产品预期”。在这篇综述中，我们调查的情况下，在实验室中合成的化合物已经从自然中分离出来。我们综述的重点在于这种对天然产物的预期已触发成功搜索或合成和分离独立发生的例子。最后，我们强调的情况下，潜在的天然产物结构已被建议作为合成努力的结果，但尚未通过分离证实，邀请合成和天然产物化学家之间的进一步合作。
Natural product synthesis remains one of the most vibrant and intellectually rewarding areas of chemistry, although the justifications for pursuing it have evolved over time. In the early years, the emphasis lay on structure elucidation and confirmation through synthesis, as exemplified by celebrated studies on cocaine, morphine, strychnine and chlorophyll. This was followed by a phase where the sheer demonstration that highly complex molecules could be recreated in the laboratory in a rational manner was enough to justify the economic expense and intellectual agonies of a synthesis. Since then, syntheses of natural products have served as platforms for the demonstration of elegant strategies, for inventing new methodology ‘on the fly’ or to demonstrate the usefulness and scope of methods established with simpler molecules. We now add another aspect that we find fascinating, viz. ‘natural product anticipation’. In this Review, we survey cases where the synthesis of a compound in the laboratory has preceded its isolation from nature. The focus of our Review lies on examples where this anticipation of a natural product has triggered a successful search or where synthesis and isolation have occurred independently. Finally, we highlight cases where a potential natural product structure has been suggested as a result of synthetic endeavours but not yet confirmed by isolation, inviting further collaborations between synthetic and natural product chemists.
登录
查看更多内容
黄嘌呤内酯的对映选择性和集体全合成
影响因子：
16.6
作者：
Feng, Juan;Lei, Xiaoqiang;Tang, Yefeng
通讯作者：
Tang, Yefeng
影响因子：
16.6
作者：
Baran, PS;O'Malley, DP;Zografos, AL
通讯作者：
Zografos, AL
影响因子：
3.6
作者：
Day, Aaron J.;Sumby, Christopher J.;George, Jonathan H.
通讯作者：
George, Jonathan H.
影响因子：
5.2
作者：
Beaudry, CM;Trauner, D
通讯作者：
Trauner, D
影响因子：
21.8
作者：
Ellerbrock, Pascal;Armanino, Nicolas;Trauner, Dirk
通讯作者：
Trauner, Dirk