Incidence of community-acquired pneumonia in children caused by Mycoplasma pneumoniae:: Serological results of a prospective, population-based study in primary health care
Incidence of community-acquired pneumonia in children caused by Mycoplasma pneumoniae:: Serological results of a prospective, population-based study in primary health care
复制标题
DOI：
10.1111/j.1440-1843.2003.00522.x
复制
发表时间：
2004-03-01
期刊：
影响因子：
6.9
通讯作者：
Kleemola, M
中科院分区：
文献类型：
--
作者：
Korppi, M;Heiskanen-Kosma, T;Kleemola, M
目的：了解肺炎支原体引起的儿童社区获得性肺炎(CAP)的发病率。方法：在1981-1982年的12个月期间，登记了所有的社区获得性肺炎病例。肺炎支原体的病原学最初采用补体结合试验(CF)，1999年辅以酶免疫分析(EIA)检测抗体。结果：201例CAP患儿中61例(30%)检出肺炎支原体，是5岁及以上儿童最常见的病原体。在这个年龄段，肺炎支原体占50%以上，支原体感染占90%以上。EIA发现了17个新病例，超过了CF检测到的44个病例，而仅CF就发现了10个病例。肺炎支原体肺炎的发病率随着年龄的增长而增加，10岁以上的儿童发病率在10/1000以上。肺炎链球菌和肺炎衣原体的混合感染分别占支原体肺炎病例的30%和15%以上。结论：肺炎支原体是初级卫生保健儿科CAP的常见病因，肺炎链球菌与肺炎衣原体混合感染较为常见。对CAP患儿使用抗生素时，应同时考虑肺炎链球菌和肺炎支原体。
Objective: The objective of the present study was to assess the incidence of community-acquired pneumonia (CAP) in children caused by Mycoplasma pneumoniae.Methodology: During 12 months in 1981-1982, all CAP cases in a defined child population were registered. M. pneumoniae aetiology, initially measured by complement fixation (CF) test, was in 1999 supplemented by measurement of IgG and IgM antibodies using enzyme immunoassays (EIA).Results: M. pneumoniae was detected in 61 (30%) of 201 paediatric CAP cases, being the most common aetiological agent in those 5 years of age or over. At that age, M. pneumoniae was responsible for over 50% of cases, and over 90% of mycoplasmal cases were treated as outpatients. The EIA detected 17 new cases over and above the 44 detected by CF, while CF alone revealed 10 cases. The incidence of M. pneumoniae CAP increased with age, being over 10/1000 children at the age of 10 years or more. Co-infections with Streptococcus pneumoniae and Chlamydia pneumoniae were present in over 30% and 15%, respectively, of mycoplasmal CAP cases.Conclusion: M. pneumoniae is a common cause of paediatric CAP in primary health care, and coinfections with S. pneumoniae are common. Both S. pneumoniae and M. pneumoniae should be taken into account when starting antibiotics for children with CAP.