Differentiation of the gastric mucosa IV. Role of trefoil peptides and IL-6 cytokine family signaling in gastric homeostasis
Differentiation of the gastric mucosa IV. Role of trefoil peptides and IL-6 cytokine family signaling in gastric homeostasis
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DOI：
10.1152/ajpgi.00382.2006
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发表时间：
2007-01-01
影响因子：
4.5
通讯作者：
Judd, L. M.
中科院分区：
文献类型：
--
作者：
Giraud, A. S.;Jackson, C.;Judd, L. M.
胃三叶肽通过刺激细胞迁移、抑制细胞凋亡和炎症并可能增强粘液的屏障功能来介导粘膜修复。其中之一，tff1，是一种胃特异性肿瘤抑制基因，当其受到抑制时，与胃癌的进展相关。 IL-6 家族细胞因子通过调节 tff1 和其他粘膜增殖、炎症、血管生成和细胞凋亡介质，在维持胃稳态中发挥重要作用。在这篇综述中，描述了有助于控制这种稳态的常见 IL-6 细胞因子家族辅助受体 gp130 下游的信号级联，以及这些通路不平衡的病理结果。
Gastric trefoil peptides mediate mucosal repair by stimulating cell migration, inhibiting apoptosis and inflammation, and likely augmenting the barrier function of mucus. One of these, tff1, is a gastric-specific tumor suppressor gene, which when repressed is associated with gastric cancer progression. IL-6 family cytokines play an important role in maintaining gastric homeostasis by regulating tff1 and other mediators of mucosal proliferation, inflammation, angiogenesis, and apoptosis. In this review the signaling cascades downstream of the common IL-6 cytokine family coreceptor gp130 that contribute to control of this homeostasis are described, as are the pathological outcomes of imbalancing these pathways.