Cortical and Subcortical Coordination of Visual Spatial Attention Revealed by Simultaneous EEG-fMRI Recording
Cortical and Subcortical Coordination of Visual Spatial Attention Revealed by Simultaneous EEG-fMRI Recording
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DOI：
10.1523/jneurosci.0326-17.2017
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发表时间：
2017-08-16
影响因子：
5.3
通讯作者：
Woldorff, Marty G.
中科院分区：
文献类型：
--
作者：
Green, Jessica J.;Boehler, Carsten N.;Woldorff, Marty G.
视觉空间注意的研究主要集中在脑电图和功能磁共振成像两个方面。然而，由于单独使用这些方法的内在局限性，我们对注意力控制的系统水平机制的理解仍然有限。在这里，我们研究了试验到试验的协变，同时记录脑电图和功能磁共振成像在人类的线索视觉空间注意力任务，它允许划定的发生器和调制器的线索触发事件相关的振荡脑活动的注意力控制功能。在视觉皮层区域的fMRI活动对侧的提示方向的注意与枕叶γ-波段EEG的共变积极，与激活的皮质区域代表出席的空间位置一致。相反，同侧视觉皮层区域的fMRI活动与枕叶α-波段振荡呈负相关，这与不相关半空间的注意力相关抑制一致。此外，丘脑枕核与这两个空间特异性，注意力相关，振荡EEG调制共变。由于枕的神经解剖学的几何形状，使其不太可能是一个直接发电机的头皮记录的脑电图，这些covariantic模式似乎反映枕的作用，作为一个监管控制结构，发送空间特定的信号，以调节视觉皮层的兴奋性主动。总之，这些组合EEG/fMRI结果照亮了动态相互作用的皮层和皮层下的空间注意的过程，提供了重要的洞察力，不能实现单独使用任何一种方法。
Visual spatial attention has been studied in humans with both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) individually. However, due to the intrinsic limitations of each of these methods used alone, our understanding of the systems-level mechanisms underlying attentional control remains limited. Here, we examined trial-to-trial covariations of concurrently recorded EEG and fMRI in a cued visual spatial attention task in humans, which allowed delineation of both the generators and modulators of the cue-triggered event-related oscillatory brain activity underlying attentional control function. The fMRI activity in visual cortical regions contralateral to the cued direction of attention covaried positively with occipital gamma-band EEG, consistent with activation of cortical regions representing attended locations in space. In contrast, fMRI activity in ipsilateral visual cortical regions covaried inversely with occipital alpha-band oscillations, consistent with attention-related suppression of the irrelevant hemispace. Moreover, the pulvinar nucleus of the thalamus covaried with both of these spatially specific, attention-related, oscillatory EEG modulations. Because the pulvinar's neuroanatomical geometry makes it unlikely to be a direct generator of the scalp-recorded EEG, these covariational patterns appear to reflect the pulvinar's role as a regulatory control structure, sending spatially specific signals to modulate visual cortex excitability proactively. Together, these combined EEG/fMRI results illuminate the dynamically interacting cortical and subcortical processes underlying spatial attention, providing important insight not realizable using either method alone.