Deformation-Based Droplet Separation in Microfluidics
Deformation-Based Droplet Separation in Microfluidics
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DOI：
10.1021/acs.iecr.9b04823
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发表时间：
2020-03-04
影响因子：
4.2
通讯作者：
Wan, Jiandi
中科院分区：
文献类型：
--
作者：
Chang, Yunju;Chen, Xinye;Wan, Jiandi
基于变形的颗粒/液滴分离在许多工业和医疗应用中是重要的。然而，颗粒/液滴的不同物理参数（例如粘度、速度和尺寸）在分选过程中的作用仍然难以捉摸。在这里，我们设计了一种具有圆柱形柱的微流体装置，该柱可以根据液滴大小，粘度和速度分离液滴。我们表明，具有大尺寸或低变形性的液滴（即，高粘度或低速度）被分离到微流控装置中的侧面出口，而具有小尺寸或高变形性的液滴离开到中心出口。利用高速成像技术，我们进一步识别了分选过程中两个连续的液滴变形，并表明由液滴物理参数决定的特征距离（delta）和撞击角（theta）在基于变形的液滴分选中起着调节作用。只有当δ>= 0.542或θ>= 28度时，液滴才分选到侧面出口。
Deformation-based particle/droplet separation is important in many industrial and medical applications. The roles of different physical parameters of particles/droplets such as viscosity, velocity, and size in the sorting process, however, remain elusive. Here, we designed a microfluidic device with a cylindrical post that can separate droplets depending on droplet size, viscosity, and velocity. We showed that droplets with a large size or low deformability (i.e., high viscosity or low velocity) were separated to side outlets in the microfluidic device, whereas droplets with a small size or high deformability exited to the center outlet. With high-speed imaging, we further identified two sequential droplet deformations during the sorting process and showed that the characteristic distance (delta) and the impact angle (theta), which were determined by the physical parameters of droplets, played a regulatory role in deformation-based droplet sorting. Droplet sorting to the side outlets occurred only when delta >= 0.542 or theta >= 28 degrees.