Effects of atrial natriuretic factor on renal handling of water and electrolytes in rats.
Effects of atrial natriuretic factor on renal handling of water and electrolytes in rats.
复制标题
心房钠尿因子对大鼠肾脏处理水和电解质的影响。
DOI：
10.1139/y83-149
复制
发表时间：
1983
影响因子：
2.1
通讯作者：
A. M. Azzarolo
中科院分区：
文献类型：
--
作者：
R. Keeler;A. M. Azzarolo
在低渗利尿期间，麻醉大鼠静脉注射心房心肌提取物，可导致肾脏水、钠、钾、钙、镁和磷酸盐的排泄增加。由于在Brattleboro （di/di）大鼠中没有出现抗利尿激素的分泌，因此尿浓度可能增加。肾小球滤过率和肾血浆流量在前5分钟短暂增加，滤过率持续升高。心房提取物的注射对水利尿的Brattleboro大鼠的无溶质水的形成也有部分抑制作用，对最大抗利尿大鼠的无溶质水的重吸收也有部分抑制作用。在这两种情况下，抑制的程度都不如注射速尿后观察到的那样深刻，而注射速尿的剂量引起了相当的利钠反应。大剂量的速尿阻断了心房提取物的利钠反应，然而，当大量输注生理盐水产生相当水平的钠和水输出时，心房提取物的利钠反应增加。提示心房利钠因子可能抑制了在髓质厚升肢以外的肾元段的钠转运。速尿也可能作用于相同的小管部位或抑制小管分泌房钠素。
The intravenous injection of an extract of atrial myocardium into anesthetized rats during a hypotonic diuresis resulted in an increase in the renal excretion of water, sodium, potassium, calcium, magnesium, and phosphate. There was an increase in urine concentration which was probably a result of the secretion of vasopressin since it did not occur in Brattleboro (di/di) rats. A transient increase in glomerular filtration rate and renal plasma flow occurred during the first five minutes with a more sustained rise in filtration fraction. Injection of atrial extract also caused a partial inhibition of solute-free water formation in Brattleboro rats subjected to water diuresis and a partial inhibition of solute-free water reabsorption in rats subjected to maximal antidiuresis by infusing vasopressin. In neither case was the degree of inhibition as profound as that observed after injecting furosemide in a dose which caused a comparable natriuretic response. A large dose of furosemide blocked the natriuretic response to atrial extracts whereas, when a comparable level of sodium and water output was produced by massive infusions of saline, the natriuretic response to atrial extract was increased. It is suggested that atrial natriuretic factor might inhibit sodium transport in nephron segments beyond the medullary thick ascending limb. Furosemide might also act at the same tubular site or inhibit tubular secretion of the atrial natriuretic factor.