The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats
The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats
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DOI：
10.1111/j.1740-0929.2009.00670.x
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发表时间：
2009-01-01
影响因子：
2
通讯作者：
Hasegawa, Shin
中科院分区：
文献类型：
--
作者：
Honda, Kazuhisa;Kamisoyama, Hiroshi;Hasegawa, Shin
甘草（Glycyrrhiza glabra）在传统药物中有着广泛的应用，其类黄酮油（LFO）可以降低哺乳动物腹部脂肪组织的重量。在本研究中，我们研究了低脂肪脂肪降低腹部脂肪组织重量的分子机制。低脂油显著降低肝脏脂肪酸合成途径限速酶mRNA水平，而低脂油显著提高肝脏脂肪酸氧化途径限速酶mRNA水平。低脂油显著降低了固醇调节元件结合蛋白-1c (SREBP-1c)（一种促进肝脂肪酸合成的转录因子）的mRNA水平，而过氧化物酶体增殖因子激活受体- α (ppar - α)（一种促进肝脂肪酸氧化的转录因子）的mRNA水平显著升高。我们的研究结果表明，低脂油对腹部脂肪组织重量的降低是由肝脏中SREBP-1c和ppar - α的转录调节介导的。因此，我们推断，天然成分LFO是一种很有前途的候选饲料添加剂，可用于减少家畜腹部脂肪的积累。
Licorice (Glycyrrhiza glabra) has been widely used in traditional medicines, and its flavonoid oil (LFO) decreases abdominal adipose tissue weight in mammals. In the present study, we investigated the molecular mechanisms underlying the decrease in abdominal adipose tissue weight by LFO. LFO significantly decreased the mRNA levels of rate-limiting enzymes in the hepatic fatty acid synthetic pathway, whereas LFO significantly increased the mRNA levels of a rate-limiting enzyme in the hepatic fatty acid oxidative pathway. LFO significantly decreased the mRNA levels of sterol regulatory element-binding protein-1c (SREBP-1c) (a transcription factor that promotes hepatic fatty acid synthesis), whereas the mRNA levels of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) (a transcription factor that promotes hepatic fatty acid oxidation) was significantly increased. All our findings suggest that the decrease in abdominal adipose tissue weight by LFO is mediated by the transcriptional regulation of SREBP-1c and PPAR-alpha in the liver. Thus, we infer that the natural ingredient LFO is a promising candidate for use as a feed additive to reduce abdominal fat accumulation in domestic animals.