DERMATOMYOSITIS
DERMATOMYOSITIS
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DOI：
10.1016/s0022-3476(64)80325-5
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发表时间：
1964-01-01
影响因子：
5.1
通讯作者：
TRAVIS, LB
中科院分区：
文献类型：
--
作者：
BITNUM, S;HOPPS, HC;TRAVIS, LB
皮肌炎是一种与其他结缔组织疾病密切相关的综合征，其临床表现广泛，一端主要累及肌肉，另一端则表现为更广泛的皮肤和内脏受累。可能存在多种病原体，但目前的13名儿童涉及未知的农业因素。诊断基本上是临床诊断，实验室检查结果要么不特异，要么不可靠。肾活检显示，在所有6例患者的研究显着，但非特异性的变化，往往没有其他肾脏疾病的证据。目前的治疗对预后没有显着贡献，尽管类固醇经常在急性期产生显着的结果，并且机械呼吸辅助装置可能可以挽救生命。
Dermatomyositis, a syndrome closely related to the other connective tissue diseases has a wide clinical spectrum involving primarily muscle at the one end, but presenting a more generalized disorder with skin and visceral involvement at the other. Multiple etiologic agents probably exist, but the present series of 13 children implicated unknown agricultural factors. The diagnosis is essentially a clinical one, the laboratory findings being either nonspecific or unreliable. Renal biopsy revealed striking but nonspecific changes in all 6 patients studied, often without other evidence of renal disease. Current therapy does not contribute significantly to the prognosis, although steroids frequently yield dramatic results in the acute stage, and mechanical respiratory aids may be life-saving.