Bacteria in Whipple's disease. Isolation of a Haemophilus strain from the jejunal propria.
Bacteria in Whipple's disease. Isolation of a Haemophilus strain from the jejunal propria.
复制标题
惠普尔病中的细菌。
DOI：
10.1111/apm.1966.66.1.135
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发表时间：
1966
期刊：
影响因子：
--
通讯作者：
Egil Gjone
中科院分区：
文献类型：
--
作者：
Asmund Kjierheim;Tore Midtvedt;Sverre Skrede;Egil Gjone
惠普尔病于1907年首次被描述（22），多年来一直被认为是一种肠道脂肪营养不良。2009年(1)，blaclc - sclwlcr在肠粘膜和肠系膜淋巴结的巨噬细胞中发现pas阳性物质，被认为支持了Vhipple病是糖蛋白代谢的原发性疾病的概念。然而，pas阳性物质的化学性质尚未得到澄清，其来源也尚未确定。在过去的几年里，……经口及小肠活检的电镜检查对该病小肠病变的病理学有了新的认识。几项研究揭示了杆状结构的存在，强烈暗示了细菌的存在。ie。Vhipple病患者的固有层（1、4、6、12、14、17、21、23）和一系列活检显示，在抗生素治疗期间，菌体消失（12、14）。pas阳性颗粒也倾向于消失，但比细菌更慢（2,9,12,14,17）。大多数作者现在似乎都同意，微生物在惠普尔病的发展中起着主要或次要的作用，显然没有必要对这些病人身上经常发现的“微生物体”进行鉴定。最近，卡罗莱·卡罗莱是一名护士。(3)从1例患者的腹股沟淋巴结中分离出一种鉴定为厌氧型大肠杆菌11111的细菌，并声称该微生物是引起维普尔病的原因。在空肠的一系列口腔活检中，/\ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \小恶魔-
Whipple's disease, first described in 1907 (22), was for many years thought to be an intestinal lipodystrophy. The demonstration of PAS-Positive material in macrophages of the intestinal mucosa and mesenteric lymph nodes, carried out hy Blaclc-Sclwlf'cr in I 049 (1), was considered to lend support to the concept of\Vhipple's disease as a primary disorder of glycoprotein metabolism. The chemistry of the PAS-positive substance in question, however, has not heen clarified, neither has its origin been definitely established.. During the last years,. electron microscopic investigations of peroral llltestinal biopsies have shed new light on the aeliology of the small bowel lesions in this disease. Several studies have revealed the presence of rod-shaped structures strongly suggestive of small bacteria in the. ie. iunnl lamina propria of patients with\Vhipple's disease (:-1, 4, 6, 12, 14, 17, 21, 2i3), and serial biopsies have demonstrated that the haclerialikc bodies disappear during antibiotic treatment (12, 14). The PAS-Positive granules also tend to disappear, hut more slowly than do the bacteria (2, 9, 12, 14, 17). Most authors now seem to agree that microorganisms play a role, primary or secondary, in the development of Whipple's disease, and obviously there exists n need for the idenlifica-Lion of the" hacillnry bodies" regularly found in these patients. Hecently, Caroli cl a/.(3) isolated a bacterium identified ns Co run ebaclerillm anaerobic11111 from an inguinal lymph node in one patient, and claimed this microorganism to he the cnuse of\Vhipple's disease. In serial peroral biopsies from the jejunum,/\ole rl a/.(lil) demon-