The role of suppression in immunoregulation.
The role of suppression in immunoregulation.
复制标题
抑制在免疫调节中的作用。
DOI：
--
复制
发表时间：
1976
影响因子：
--
通讯作者：
R. Gershon
中科院分区：
文献类型：
--
作者：
R. Gershon
作为抗原反应性克隆的缺失的耐受性的经典概念最近受到双管齐下的攻击。已经表明，至少某些形式的耐受性（如果存在多于一种形式）是由于抗原抗体复合物和/或抑制性T细胞对潜在反应性克隆的主动抑制。此时，后一种抑制机制似乎在免疫学思想中占优势。这反映在本次会议上提交的论文中，以及其组织层次结构中;抑制T细胞专家是抑制会议的主席，而抗原抗体复合物概念的创始人已被降级为联合主席。然而，领跑者已经被称为褪色，如果有一件事是明确的主题，这是最后的答案还没有。希望在会议结束时，我们将比撰写本文时更接近它。
The classical notion of tolerance as a deletion of antigen reactive clones has recently come under a two-pronged attack. It has been suggested that at least some forms of tolerance (if there is more than one form) are due to active suppression of potentially reactive clones by antigen antibody complexes and/or suppressor T cells. At this moment the latter mechanism of suppression seems to be in ascendency in immunological thought. This is mirrored in the papers being presented at this conference, as well as in its organizational hierarchy; a suppressor T cell maven is the chairman of the session on suppression while the originator of the antigen antibody complex notion has been relegated to co-chairman status. However, front runners have been known to fade and if one thing is clear about the subject, it is that the final answer is not yet in. Hopefully, at the conclusion of the conference we will be closer to it than we are at the moment of this writing.