Overview of radiation-induced skin cancer in humans.
Overview of radiation-induced skin cancer in humans.
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辐射诱发的人类皮肤癌概述。
DOI：
10.1080/09553009014550951
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发表时间：
1990
影响因子：
2.6
通讯作者：
Shore,RE
中科院分区：
文献类型：
--
作者：
Shore,RE
大约有十几项关于已知皮肤剂量的受辐照人口皮肤癌发病率的研究可用于估计辐射诱发皮肤癌的风险。值得注意的是，它们没有提供剂量阈值的证据，并且与线性剂量-反应关系相容，至少对于紫外线辐射暴露的皮肤是如此。这些研究还提供了有关评估皮肤癌风险的许多其他重要问题的不同数量的证据：电离辐射诱发的皮肤癌类型、相对风险与绝对风险模型的适当性、电离辐射和紫外线辐射的综合影响以及敏感性的变化人口和遗传亚群之间对皮肤癌诱发的差异。关于几个因素的流行病学资料很少，如高LET辐射的RBE、剂量延长或分次的影响或辐照时年龄的风险变化。当按鳞状细胞和基底细胞皮肤癌的相对比例加权时，皮肤癌致死率的合理估计为0.2%。辐射诱发皮肤癌发病率的平均风险估计值为：绝对风险（AR）为8.5 × 10− 4人-年-Sv，超额相对风险（RR）为52%/Sv。通过寿命表方法计算了20-60岁年龄段男性的终生皮肤癌风险。在AR和RR模型下，皮肤癌发病率分别为2%和11%/Sv，而相应的死亡风险分别为4 × 10− 5和2 × 10− 4/Sv。
There are about a dozen studies of the incidence of skin cancer among irradiated populations with known skin doses that are available for estimating the risk of radiation-induced skin cancer. It is of note that they provide no evidence for a dose threshold and are compatible with a linear dose–response relationship, at least for ultraviolet radiation exposed skin. The studies also provide varying amounts of evidence concerning a number of other important issues in assessing skin cancer risk: types of skin cancer induced by ionizing radiation, the appropriateness of relative risk vs absolute risk models, combined effects of ionizing and UV radiations, and variations in sensitivity to skin cancer induction among demographic and genetic subgroups. Little epidemiological information is available on several factors, such as the RBE for high-LET radiation, the effects of dose protraction or fractionation, or variations in risk by age at irradiation. A reasonable estimate of skin cancer lethality was 0·2 per cent when weighted for the relative proportions of squamous cell and basal cell skin cancers. Average risk estimates of radiation-induced skin cancer incidence were: absolute risk (AR) of 8·5 × 10−4person-year-Sv and excess relative risk (RR) of 52 per cent/Sv. Lifetime skin cancer risk was calculated by life-table methods for males from exposures spread out over ages 20–60 years. The estimates for excess skin cancer incidence were 2 per cent and 11 per cent per Sv under the AR and RR models, respectively, while the corresponding mortality risks were 4 × 10−5and 2 × 10−4per Sv.
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衰老对果蝇分离扭曲现象的影响。
影响因子：
3.3
作者：
Y. Hiraizumi;S. Watanabe
通讯作者：
S. Watanabe
多重分离扭曲 (SD) 染色体对果蝇精子功能障碍的累加效应。
影响因子：
3.3
作者：
T. W. Lyttle
通讯作者：
T. W. Lyttle
果蝇的生物学参数和分离扭曲（SD）现象。
影响因子：
3.3
作者：
G. Trippa;R. Cicchetti;A. Loverre;A. Micheli
通讯作者：
A. Micheli
与果蝇分离扭曲现象相关的遗传元件的进一步表征。
影响因子：
3.3
作者：
C. B. Sharp;A. Hilliker;D. Holm
通讯作者：
D. Holm
有证据表明，sisterless-a 和sisterless-b 是果蝇X/A 性别决定信号的几个离散“分子元件”中的两个，可在两种替代稳定表达状态之间切换Sxl。
影响因子：
3.3
作者：
Cline,TW
通讯作者：
Cline,TW