Expression of PADI4 during rheumatoid arthritis development
Expression of PADI4 during rheumatoid arthritis development
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PADI4在类风湿性关节炎发生过程中的表达
DOI：
10.4081/rr.2009.e3
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Yunzhong Zhang
中科院分区：
文献类型：
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作者：
Cuirong Bian;X. Chang;Yan Zhao;J. Jia;Yunzhong Zhang
肽基脱亚胺酶4（PADI 4）催化肽基精氨酸生成瓜氨酸。在某些人群中，编码PADI4的基因与类风湿性关节炎（RA）相关。使用ELISA在患有RA和骨关节炎（OA）少于六个月的患者的血液中测量PADI 4、抗CCP和RF的水平。这些水平也在被诊断患有RA超过三年的患者的血液中进行了测量。作为对照，还测定了来自健康受试者或患有强直性脊柱炎（AS）、流行性胸膜痛（EP）、OA、银屑病关节炎（PA）、系统性红斑狼疮（SLE）、痛风性关节炎（GA）或斯蒂尔病（ST）的患者的样品。在早期RA患者中，68.7%的患者的PADI 4水平显著高于早期OA患者。RA患者较SLE、ST和GA患者PADI 4的表达更高，但与健康受试者或AS、EP、OA或PA患者相似。RA患者血浆PADI 4水平与RF和抗CCP抗体水平显著相关，而其他疾病患者和健康人血浆PADI 4水平与RF和抗CCP抗体水平无相关性。PADI4水平与疾病活动性和临床表现有关。
Peptidyl deiminase 4 (PADI4) catalyzes peptidylarginine to citrulline. The gene encoding PADI4 is associated with rheumatoid arthritis (RA) in some populations. The levels of PADI4, anti-CCP, and RF were measured in the blood of patients suffering from RA and osteoarthritis (OA) for less than six months using ELISA. The levels were also measured in the blood of patients that have been diagnosed with RA for more than three years. As controls, samples from healthy subjects or patients with ankylosing spondylitis (AS), epidemic pleurodynia (EP), OA, psoriatic arthritis (PA), systemic lupus erythematosus (SLE), gouty arthritis (GA), or Still’s disease (ST) were also assayed. Of patients with early RA, 68.7% had significantly higher levels of PADI4 than patients with early OA. Patients with RA for a longer period of time had a higher expression of PADI4 than patients with SLE, ST, and GA, but they were similar to healthy subjects or patients with AS, EP, OA, or PA. The level of PADI4 was significantly correlated to the levels of RF and anti-CCP in blood samples of RA, but not in the samples of other diseases and those of healthy subjects. The level of PADI4 relates to the disease activity and clinical performance.
肽基精氨酸脱亚胺酶 4 (PADI4) 和瓜氨酸蛋白在类风湿性关节炎滑膜组织中的定位
DOI：
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发表时间：
2006
期刊：
Rheumatology 44・1
影响因子：
--
作者：
Chang X;Yamada R;Suzuki A;Sawada T;Yoshino S;Tokuhiro S;Yamamoto K
通讯作者：
Yamamoto K