Aromatic amination of aryl bromides catalysed by copper/β-diketone catalysts:: The effect of concentration
Aromatic amination of aryl bromides catalysed by copper/β-diketone catalysts:: The effect of concentration
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DOI：
10.1055/s-2006-951510
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发表时间：
2006-11-03
期刊：
影响因子：
2
通讯作者：
de Vries, Johannes G.
中科院分区：
文献类型：
--
作者：
de Lange, Ben;Lambers-Verstappen, Marielle H.;de Vries, Johannes G.
CuCl与β-二酮的配位催化剂对溴代芳烃的胺化反应具有良好的催化活性。关键是底物的浓度：在5 M时，速率和选择性显著提高。此外，K2 CO 3可以代替昂贵的Cs2 CO 3用作碱。伯胺、仲胺、杂环化合物和苯胺都可以很好地芳基化。
CuCl ligated with beta-diketones were found to be good catalysts for the amination of aryl bromides. Crucial is the concentration of the substrates: at 5 M the rate and selectivity improves substantially. In addition, K2CO3 can be used as base instead of expensive CS2CO3. Primary and secondary amines, heterocycles and anilines could be arylated in good yields.