Comorbidity and outcomes in traumatic brain injury: protocol for a systematic review on functional status and risk of death.
Comorbidity and outcomes in traumatic brain injury: protocol for a systematic review on functional status and risk of death.
复制标题
创伤性脑损伤的合并症和结果：功能状态和死亡风险系统评价方案。
DOI：
10.1136/bmjopen-2017-018626
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发表时间：
2017
期刊：
影响因子：
2.9
通讯作者：
Colantonio,Angela
中科院分区：
文献类型：
--
作者：
Mollayeva,Tatyana;Xiong,Chen;Hanafy,Sara;Chan,Vincy;Hu,ZhengJing;Sutton,Mitchell;Escobar,Michael;Colantonio,Angela
引言关于合并症与创伤性脑损伤（TBI）患者功能状态和死亡风险之间关系的报告不一致;目前尚不清楚哪些额外的临床实体（合并症）对TBI男性和女性患者生命周期内结局的演变产生不利影响。目前的研究方案概述了一项系统评价现有证据的策略，这些证据检查了合并症对功能状态以及早期和晚期死亡率的影响，并考虑了这些不良结局的已知风险因素（即，人口统计学（年龄和性别）和损伤相关特征）。方法和分析TBI预后的综合搜索策略，与大型康复教学医院的医疗信息专家合作，开展了功能（认知和身体）状况和死亡率研究。所有在1997年5月至2017年4月期间发表的、通过Medline、Central、Embase、Scopus、PsycINFO和已识别文章的参考书目找到的、在任何严重程度的TBI成人中采用纵向设计的同行评审英语研究都将被视为合格。研究质量将使用已发表的指南进行评估。伦理和传播作者将在同行评审的科学期刊上发表本综述的结果，并在国家和国际会议上展示结果。这项工作的目的是了解合并症如何可能有助于TBI的不良后果，告知患者的风险分层，并指导急性脑损伤的管理，并在人群水平上的慢性阶段postinjury。
IntroductionReports on the association between comorbidity and functional status and risk of death in patients with traumatic brain injury (TBI) have been inconsistent; it is currently unknown which additional clinical entities (comorbidities) have an adverse influence on the evolution of outcomes across the lifespan of men and women with TBI. The current protocol outlines a strategy for a systematic review of the current evidence examining the impact of comorbidity on functional status and early-term and late-term mortality, taking into account known risk factors of these adverse outcomes (ie, demographic (age and sex) and injury-related characteristics).Methods and analysisA comprehensive search strategy for TBI prognosis, functional (cognitive and physical) status and mortality studies has been developed in collaboration with a medical information specialist of the large rehabilitation teaching hospital. All peer-reviewed English language studies with longitudinal design in adults with TBI of any severity, published from May 1997 to April 2017, found through Medline, Central, Embase, Scopus, PsycINFO and bibliographies of identified articles, will be considered eligible. Study quality will be assessed using published guidelines.Ethics and disseminationThe authors will publish findings from this review in a peer-reviewed scientific journal(s) and present the results at national and international conferences. This work aims to understand how comorbidity may contribute to adverse outcomes in TBI, to inform risk stratification of patients and guide the management of brain injury acutely and at the chronic stages postinjury on a population level.PROSPERO registration numberCRD42017070033.