Food and botanical groupings and risk of breast cancer: a case-control study in Shanghai, China.
Food and botanical groupings and risk of breast cancer: a case-control study in Shanghai, China.
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DOI：
10.1158/1055-9965.81.14.1
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发表时间：
2005-01
期刊：
影响因子：
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通讯作者：
J. Shannon;R. Ray;Chenyuan Wu;Zakia Coriaty Nelson;D. Gao;Wenjin Li;Wei Hu;J. Lampe;N. Horner;J. Satia;R. Patterson;Dawn Fitzgibbons;P. Porter;D. Thomas
中科院分区：
文献类型：
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作者：
J. Shannon;R. Ray;Chenyuan Wu;Zakia Coriaty Nelson;D. Gao;Wenjin Li;Wei Hu;J. Lampe;N. Horner;J. Satia;R. Patterson;Dawn Fitzgibbons;P. Porter;D. Thomas
当中国女性从中国移居到香港再到美国时，乳腺癌发病率增加了一倍以上，这表明环境因素导致了乳腺癌发病率的国际差异。美国和中国人群的一些饮食因素有所不同，包括大豆、肉类、水果和蔬菜的摄入量，这些因素被认为会影响乳腺癌风险。本报告描述了中国上海一项乳房自我检查随机试验中饮食与乳腺癌风险的病例对照研究的结果。参与的乳腺癌病例 (n = 378) 和频率年龄匹配的对照 (n = 1,070) 完成了综合食物频率调查问卷和危险因素调查问卷。调整年龄、总能量摄入量和母乳喂养总年数后，与摄入量最低四分位数（或 = 6.0 个鸡蛋/周与 < 或 = 2.0 个鸡蛋/周）的女性相比，水果和蔬菜摄入量最高四分位数（> 或 = 3.8 份/天）的女性患乳腺癌的可能性显着降低（比值比，0.48；95% 置信区间，0.29-0.78）。 0.56； 95% 置信区间，0.35-0.91）。病例和对照之间的大豆消费量没有差异。与单一植物科的关联都无法解释水果和蔬菜与乳腺癌风险之间的强烈负相关关系。这些结果提供了额外的证据来支持水果和蔬菜在预防乳腺癌中的重要作用。
Breast cancer incidence rates more than double in Chinese women as they migrate from China to Hong Kong to the United States, suggesting that environmental factors contribute to the international variation in breast cancer incidence. Several dietary factors, which differ between the United States and the Chinese population, including intake of soy, meat, and fruits and vegetables, have been suggested to affect breast cancer risk. This report describes results from a case-control study of diet and risk of breast cancer nested in a randomized trial of breast self exam in Shanghai, China. Participating breast cancer cases (n = 378) and frequency age-matched controls (n = 1,070) completed a comprehensive food frequency questionnaire and a risk factor questionnaire. After adjustment for age, total energy intake, and total years of breast-feeding, women in the highest quartile of fruit and vegetable intake (> or =3.8 servings/d) were significantly less likely to have breast cancer (odds ratio, 0.48; 95% confidence interval, 0.29-0.78) as compared with women in the lowest quartile of intake ( or =6.0 eggs/wk versus < or =2.0 eggs/wk is 0.56; 95% confidence interval, 0.35-0.91). There was no difference in soy consumption between cases and controls. None of the associations with a single botanical family explained the strong inverse relationship between fruits and vegetables and breast cancer risk. These results provide additional evidence in support of the important role of fruits and vegetables in breast cancer prevention.