ULTRARAPID HIGH-DOSE IRRADIATION SCHEDULES FOR THE PALLIATION OF BRAIN METASTASES - FINAL RESULTS OF THE 1ST 2 STUDIES BY THE RADIATION-THERAPY ONCOLOGY GROUP
ULTRARAPID HIGH-DOSE IRRADIATION SCHEDULES FOR THE PALLIATION OF BRAIN METASTASES - FINAL RESULTS OF THE 1ST 2 STUDIES BY THE RADIATION-THERAPY ONCOLOGY GROUP
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DOI：
10.1016/0360-3016(81)90184-x
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发表时间：
1981-01-01
影响因子：
7
通讯作者：
ROTH, R
中科院分区：
文献类型：
--
作者：
BORGELT, B;GELBER, R;ROTH, R
1971 年 1 月至 2 月1976年，放射治疗肿瘤学组将1902名可评估患者纳入两项连续的III期国家合作试验，以研究不同时间剂量放射治疗方案对脑转移患者姑息治疗的有效性。每项试验均包括一个可选组，患者被随机分配接受 1000 rad/1 分数（26 名患者，第一项研究）或 1200 rad/2 分数（33 名患者，第二项研究）。与由同一参与机构随机分配接受更长时间照射（2000、3000 或 4000 拉德/1-4 周）的 143 名对照患者进行了比较。根据神经功能改善的百分比评估，接受超快速治疗的患者的反应与接受更长期治疗的患者的反应相当。神经功能改善的及时性、治疗发病率和中位生存期也与接受 2000-4000 拉德治疗的患者相当。对于接受 1000 或 1200 拉德的患者来说，改善的持续时间、神经系统状态进展的时间以及神经系统症状完全消失的比率通常较短。对于脑转移患者的姑息治疗来说，超快速、高剂量照射方案可能不如较高剂量方案有效。
Between Jan. 1971-Feb. 1976, the Radiation Therapy Oncology Group entered 1902 evaluable patients into 2 sequential Phase III national cooperative trials to study the effectiveness of different time dose radiotherapy schemes on the palliation of patients with brain metastases. Each trial included an optional arm into which patients were randomized to receive 1000 rad/1 fraction (26 patients, 1st study) or 1200 rad/2 fractions (33 patients, 2nd study). Comparisons were made with 143 control patients randomized by the same participating institutions to receive a more protracted course of irradiation (2000, 3000 or 4000 rad/1-4 wk). Response of patients receiving ultra-rapid treatment, as assessed by the percent who had improvement in neurologic function, was comparable to that of patients receiving the more protracted schedules. Promptness of neurologic function improvement, treatment morbidity and median survival were also comparable to those of patients receiving 2000-4000 rad. The duration of improvement, time to progression of neurologic status and rate of complete disappearance of neurologic symptoms were generally less for those patients who received 1000 or 1200 rad. Ultra-rapid, high dose irradiation schedules may not be as effective as higher dose schedules in the palliation of patients with brain metastases.