Serum vascular endothelial growth factor level is elevated in patients with impaired glucose tolerance and type 2 diabetes mellitus
Serum vascular endothelial growth factor level is elevated in patients with impaired glucose tolerance and type 2 diabetes mellitus
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DOI：
10.1177/0300060519872033
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发表时间：
2019-09-23
影响因子：
1.6
通讯作者：
Wang, Guang
中科院分区：
文献类型：
--
作者：
Sun, Xiaomeng;Zhang, Heng;Wang, Guang
目的探讨血管内皮生长因子（VEGF）在糖耐量低减（IGT）和新诊断2型糖尿病（T2 DM）患者血清中的水平。方法189例受试者（正常对照组41例，糖耐量减低组40例，初诊2型糖尿病组108例）进行研究。通过ELISA测定血清VEGF水平;通过标准实验室方法评估其他代谢参数。结果T2 DM组、IGT组与对照组血清VEGF水平差异有统计学意义（T2 DM与对照组：72.00 [45.40，98.35] pg/mL与53.10 [36.30，116.25] pg/mL; IGT与对照组：78.17 [55.52，137.25] pg/mL与53.10 [36.30，116.25] pg/mL）。此外，血清VEGF水平与胰岛素抵抗的稳态模型评估（HOMA-IR）值呈正相关。多元线性回归分析显示HOMA-IR值是血清VEGF水平升高的独立危险因素。结论IGT和T2 DM患者血清VEGF水平均高于对照组，且血清VEGF水平与HOMA-IR值呈正相关。因此，血清VEGF水平升高可能部分是由于这些患者胰岛素抵抗增加所致。
Objective This study was performed to investigate the serum vascular endothelial growth factor (VEGF) levels in Chinese patients with impaired glucose tolerance (IGT) and newly diagnosed type 2 diabetes mellitus (T2DM). Methods A total of 189 subjects (41 controls, 40 patients with IGT, and 108 patients with newly diagnosed T2DM) were recruited. Serum VEGF levels were determined by ELISA; other metabolic parameters were assessed by standard laboratory methods. Results There were significant differences in serum VEGF levels among the T2DM, IGT, and control groups (T2DM vs. controls: 72.00 [45.40, 98.35] pg/mL vs. 53.10 [36.30, 116.25] pg/mL; IGT vs. controls: 78.17 [55.52, 137.25] pg/mL vs. 53.10 [36.30, 116.25] pg/mL). Moreover, serum VEGF levels were positively associated with the homeostasis model assessment for insulin resistance (HOMA-IR) value. Multiple linear regression analysis indicated that the HOMA-IR value was an independent risk factor for elevated serum VEGF level. Conclusions Both IGT and T2DM patients exhibited increased serum VEGF levels, compared with controls; increased serum VEGF level was positively associated with the HOMA-IR value. Therefore, the increased serum VEGF level might partially result from increased insulin resistance in these patients.