Inflamed skin predisposes to sensitization to less potent allergens
Inflamed skin predisposes to sensitization to less potent allergens
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DOI：
10.1016/j.jaad.2016.03.010
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发表时间：
2016-08-01
影响因子：
13.8
通讯作者：
Nedorost, Susan
中科院分区：
文献类型：
--
作者：
Kohli, Nita;Nedorost, Susan
背景：刺激性皮炎是由特应性皮炎或手部湿性皮炎的遗传屏障功能障碍引起的，可诱导先天免疫反应，可能导致对效力较低的过敏原的过敏性接触性致敏。目的：我们试图确定较弱的过敏原斑贴试验结果在有儿童屈曲性皮炎病史或当前湿工作的患者中更常见。方法：我们检查了我们的数据库，患者到接触性皮炎诊所对潜在的接触性过敏原进行检测，根据他们的病史。我们对我们最新标准中的过敏原进行了研究，看看它们是不是可以根据当地淋巴结化验的公布数据分为弱、中、强三种致敏剂。根据作为特应性皮炎替代指标的儿童期屈曲皮炎病史和职业对患者进行分层。结果：儿童期皮炎病史易接触弱敏感剂过敏和湿性工作中效敏剂。限制：协会不能证明原因。结论：我们得出结论：强致敏剂不需要湿性工作或特应性反应来引起致敏。与儿童湿疹和湿工作相关的屏障缺陷可能会促进对弱抗原的敏化。
Background: Irritant dermatitis, caused by genetic barrier dysfunction in atopic dermatitis or wet work in hand dermatitis, induces innate immune response that might predispose to allergic contact sensitization to less potent sensitizers.Objectives: We sought to determine if positive patch test results to less potent allergens are more prevalent in patients with a history of childhood flexural dermatitis or current wet work.Methods: We examined our database of patients presenting to a contact dermatitis clinic tested to potential contact allergens as indicated by their history. Allergens from our most recent standard were studied if they could be classified as weak, moderate, or strong sensitizers based on published data from the local lymph node assay. Patients were stratified by a history of childhood-onset flexural dermatitis as a proxy for atopic dermatitis and by occupation.Results: History of childhood-onset dermatitis predisposed to contact allergy to weak sensitizers and wet work to medium-potency sensitizers. Neither predisposed to contact allergy from strong sensitizers.Limitations: Association cannot prove causation.Conclusions: We conclude that strong sensitizers do not require wet work or atopy to cause sensitization. Barrier defects associated with childhood eczema and wet work may promote sensitization to weak antigens.