Interrogating the Effect of Assay Media on the Rate of Virus Inactivation of High‐Touch Copper Surfaces: A Materials Science Approach
Interrogating the Effect of Assay Media on the Rate of Virus Inactivation of High‐Touch Copper Surfaces: A Materials Science Approach
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DOI：
10.1002/admi.202200390
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发表时间：
2022-05
影响因子：
5.4
通讯作者：
C. Glover;Tsuyoshi Miyake;Victor Wallemacq;Jamie D. Harris;J. Emery;D. Engel;S. McDonnell;J. Scully
中科院分区：
文献类型：
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作者：
C. Glover;Tsuyoshi Miyake;Victor Wallemacq;Jamie D. Harris;J. Emery;D. Engel;S. McDonnell;J. Scully
被感染的身体分泌物飞沫污染的高接触表面是已知的病毒传播途径。据报道，铜表面通过释放铜离子在几分钟后使人类冠状病毒失活。在高接触表面使用铜合金可能是预防下一次大流行的关键先发制人的策略。了解铜和铜合金在现实条件下灭活病毒的真正功效，对于调整合金的固有特征（如成分、晶粒取向和表面属性）以优化抗病毒功能至关重要。然而，病毒灭活的测量依赖于检测介质（AM）溶液作为病毒载体的存在，而其对纯铜表面特性的影响（调节氧化铜释放）以前是未知的。本文研究了AM的这些特性以及AM对纯铜表面病毒灭活效果的影响。这一过程揭示了在模拟现实生活条件下，与暴露于传统AM相比，病毒半衰期减少了五倍。这项研究强调了一个概念，即在铜表面灭活病毒可能比以前认为的要有效得多。
Contamination of high‐touch surfaces with infected droplets of bodily secretions is a known route of virus transmission. Copper surfaces have been reported to inactivate human coronaviruses after several minutes, via the release of Cu cations. Utilization of copper alloys for high‐touch surfaces can be a pivotal preemptive strategy for preventing the next pandemic. Understanding the true efficacy by which copper, and copper alloys, inactivate the virus under realistic conditions is essential for tuning intrinsic alloy features such as composition, grain orientation, and surface attributes, to optimize for antiviral function. However, virus inactivation measurements depend on the presence of an assay media (AM) solution as a carrier for the virus, and its effects on the surface properties of pure copper that regulate oxidative copper release are previously unknown. Herein, these properties and the influence of AM on the efficacy of virus inactivation occurring on the surface of pure copper are investigated. The process is uncovered by which a five‐fold decrease in virus half‐life is observed in simulated real‐life conditions, relative to exposure to traditional AM. The investigation highlights the notion that virus inactivation on copper surfaces may be significantly more effective than previously thought.