Quantitative analyses of pediatric cervical spine ossification patterns using computed tomography.
Quantitative analyses of pediatric cervical spine ossification patterns using computed tomography.
复制标题
使用计算机断层扫描对儿科颈椎骨化模式进行定量分析。
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
N. Rangarajan
中科院分区：
文献类型：
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作者：
N. Yoganandan;F. Pintar;S. Lew;Raj D. Rao;N. Rangarajan
本研究的目的是量化人类儿童颈椎的骨化过程。根据临床方案，从高分辨率扫描仪上获得计算机断层扫描图像。我们使用骨窗图像来识别101例儿童寰椎、中椎和C3椎的原发性软骨联合软骨的存在。使用逻辑回归的原理来确定每个椎体的每个关节联合的概率分布作为受试者年龄的函数。给出了描述概率曲线的每个数据集的均值和95%上下限置信区间。后路骨化先于双侧前路软骨联合闭合。然而，骨化发生在不同的年龄。不同软骨联合闭合的Logistic回归结果显示，寰椎的p值<0.001，轴椎的p值为0.002至<0.001，C3椎体的p值为0.021至0.005。三、二、一并发软骨的概率为50%，分别发生在2.53岁、6.97岁和7.57岁；轴龄分别为3.59、4.74、5.7岁；第三颈椎的年龄分别为1.28岁、2.22岁和3.17岁。不同年龄发生的骨化表明骨生长/强度的成熟度不均匀。他们为重新检查假人、缩放过程和损伤指标提供了解剖学基础，以提高对儿科颈部损伤的理解。
The objective of the present study was to quantify ossification processes of the human pediatric cervical spine. Computed tomography images were obtained from a high resolution scanner according to clinical protocols. Bone window images were used to identify the presence of the primary synchondroses of the atlas, axis, and C3 vertebrae in 101 children. Principles of logistic regression were used to determine probability distributions as a function of subject age for each synchondrosis for each vertebra. The mean and 95% upper and 95% lower confidence intervals are given for each dataset delineating probability curves. Posterior ossifications preceded bilateral anterior closures of the synchondroses in all vertebrae. However, ossifications occurred at different ages. Logistic regression results for closures of different synchondrosis indicated p-values of <0.001 for the atlas, ranging from 0.002 to <0.001 for the axis, and 0.021 to 0.005 for the C3 vertebra. Fifty percent probability of three, two, and one synchondroses occurred at 2.53, 6.97, and 7.57 years of age for the atlas; 3.59, 4.74, and 5.7 years of age for the axis; and 1.28, 2.22, and 3.17 years of age for the third cervical vertebrae, respectively. Ossifications occurring at different ages indicate non-uniform maturations of bone growth/strength. They provide an anatomical rationale to reexamine dummies, scaling processes, and injury metrics for improved understanding of pediatric neck injuries.