Putting the brakes on transcription at damaged chromatin: Do Polycomb silencers do more than modify histones?
Putting the brakes on transcription at damaged chromatin: Do Polycomb silencers do more than modify histones?
复制标题
在受损染色质处抑制转录：Polycomb 沉默剂的作用不仅仅是修饰组蛋白吗？
DOI：
10.1080/23723556.2016.1244513
复制
发表时间：
2016
影响因子：
2.1
通讯作者：
Kee,Younghoon
中科院分区：
文献类型：
--
作者：
Kee,Younghoon
对DNA损伤的细胞反应之一是监测并暂时阻止染色质损伤处的RNA合成。Polycomb消音器BMI1是这一过程的著名贡献者。我们最近描述了一种新的模式，BMI1介导的转录停滞在病变，涉及UBR 5 E3连接酶和FACT组蛋白伴侣。
One of the cellular responses to DNA damage is to monitor and execute temporary arrest of RNA synthesis at chromatin lesions. The Polycomb silencer BMI1 is a well-known contributor to this process. We recently described a new mode of BMI1-mediated transcription arrest at lesions that involves UBR5 E3 ligase and FACT histone chaperon.