Time course of airway hyperresponsiveness induced by ozone in dogs.
Time course of airway hyperresponsiveness induced by ozone in dogs.
复制标题
臭氧引起狗气道高反应性的时间过程。
DOI：
10.1152/jappl.1983.55.4.1232
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Nadel,JA
中科院分区：
文献类型：
--
作者：
Holtzman,MJ;Fabbri,LM;Skoogh,BE;O'Byrne,PM;Walters,EH;Aizawa,H;Nadel,JA
为了更好地了解臭氧诱导的呼吸道高反应性的机制，我们在狗身上测定了臭氧效应的时间进程。为此，我们评估了臭氧暴露前、臭氧暴露后1小时、1天和1周的呼吸道反应性。为了评估反应性，我们麻醉了狗，并获得了输送到呼吸道的乙酰胆碱或组胺气雾剂浓度增加对肺阻力的剂量-反应曲线。在狗清醒的情况下进行臭氧暴露，并在曝光室中休息2小时，通过鼻和口以2.2ppm的水平呼吸或通过气管切开以1.0ppm的水平呼吸。对于乙酰胆碱和组胺以及两种臭氧给药途径，气道反应性在臭氧后1h最显著增加，1d后略有增加，1wk时恢复到对照水平。这一结果与我们之前对人类的研究相似，后者表明臭氧诱导的高反应性在暴露后不久就会发生，并且是快速可逆的，表明臭氧效应与呼吸道的急性炎症反应有关。
To better understand the mechanism of ozone-induced airway hyperresponsiveness we determined the time course of the ozone effect in dogs. To do this we assessed airway responsiveness before ozone exposure and then at 1 h, 1 day, and 1 wk after ozone exposure. To assess responsiveness we anesthetized the dogs and obtained dose-response curves of increasing concentrations of acetylcholine or histamine aerosols delivered to the airways vs. pulmonary resistance. Ozone exposures were carried out with the dogs awake and at rest in an exposure chamber for 2 h breathing either through the nose and mouth at a level of 2.2 ppm or through a tracheostomy at a level of 1.0 ppm. For both acetylcholine and histamine and for both routes of ozone delivery airway responsiveness increased most markedly at 1 h after ozone, increased to a lesser degree 1 day later, and returned to control levels by 1 wk. The results are similar to our previous studies in humans that showed that ozone-induced hyperresponsiveness occurs shortly after exposure and is rapidly reversible and suggest that the ozone effect is linked to an acute inflammatory response in the airways.