Noninvasive ventilatory monitoring by respiratory inductive plethysmography in conscious sheep.
Noninvasive ventilatory monitoring by respiratory inductive plethysmography in conscious sheep.
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通过呼吸感应体积描记法对有意识的羊进行无创通气监测。
DOI：
10.1152/jappl.1981.51.6.1657
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Sackner,MA
中科院分区：
文献类型：
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作者：
Abraham,WM;Watson,H;Schneider,A;King,M;Yerger,L;Sackner,MA
呼吸感应体积描记器是一种非侵入性设备，已被用于测量人体潮气量（VT），通过放置在胸腔和腹部周围的振荡器电路激发的线圈自感的变化。我们研究了它的准确性，在清醒的绵羊利用一种新的校准程序在安静的呼吸和呼吸与雾化卡巴胆碱引起的支气管痉挛。七只绵羊用鼻气管导管和食管球囊插管，用于测定经尿道压力。绵羊的基线平均肺血流阻力（RL）为1.5 +/- 0.7（SD）cmH 2 O × l-1 × s。吸入卡巴胆碱后，平均RL增加至最大值8.8 +/- 2.8 cmH 2 O X l-1 X s（P <0.002）。在基线时，通过呼吸感应体积描记法估计的20秒内的平均VT在肺量测定法的+/- 6%范围内。卡巴胆碱后，5只绵羊的VT保持接近初始验证，但在2只绵羊中，它偏离肺量测定+/- 11%。对连续记录的呼吸时间和容量成分的分析显示，支气管激发并没有显著改变平均VT或频率。然而，两个参数略有增加，导致每分钟通气量从7.6 +/- 2.4 l/min增加至9.6 +/- 2.8 l/min（P <0.02）。类似地，吸气时间的轻微下降加上VT的轻微上升使平均呼吸流量从基线值0.35 +/- 0.12增加到0.44 +/- 0.17 l/s（P <0.05）。这些结果表明，呼吸感应体积描记法准确地监测呼吸模式清醒绵羊，即使在严重的支气管痉挛。
The respiratory inductive plethysmograph is a noninvasive device that has been used to measure tidal volume (VT) in humans from changes in self-inductance of wire coils excited by an oscillator circuit placed about the rib cage and abdomen. We investigated its accuracy in conscious sheep utilizing a new calibration procedure during quiet breathing and breathing associated with bronchospasm provoked by aerosolized carbachol. Seven sheep were intubated with a nasotracheal tube and an esophageal balloon placed for determination of transpulmonary pressure. Base-line mean pulmonary flow resistance (RL) in the sheep was 1.5 +/- 0.7 (SD) cmH2O X l–1 X s. After carbachol inhalation, mean RL increased to a maximum of 8.8 +/- 2.8 cmH2O X l–1 X s (P less than 0.002). AT base line, mean VT estimated by respiratory inductive plethysmography over a 20-s period fell within +/- 6% of spirometry. After carbachol VT in five of the sheep remained close to the initial validation, but in two, it deviated +/- 11% from spirometry. Analysis of the continuous recording of timing and volume components of the breaths revealed that bronchoprovocation did not significantly alter mean VT or frequency. However, there was a slight increase in both parameters resulting in an increase in minute ventilation from 7.6 +/- 2.4 to 9.6 +/- 2.8 l/min (P less than 0.02). Similarly, a slight decline in inspiratory time coupled with the slight rise in VT produced an increase in mean respiratory flow from a base-line value of 0.35 +/- 0.12 to 0.44 +/- 0.17 l/s (P less than 0.05). These results indicate that the respiratory inductive plethysmography accurately monitors breathing pattern in conscious sheep even during severe bronchospasm.