Randomized trial of Permissive hypercapnia in preterm infants
Randomized trial of Permissive hypercapnia in preterm infants
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早产儿允许性高碳酸血症的随机试验
DOI：
10.1177/0973217920000110
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发表时间：
2000
影响因子：
--
通讯作者：
Carlo Wa
中科院分区：
文献类型：
--
作者：
Mariani G;C. J;Carlo Wa
尽管呼吸护理取得了重要进展，但肺损伤仍然是接受通气支持的新生儿发病的主要原因。辅助通气的持续时间和强度是肺损伤发展的重要决定因素。用于实现新生儿正常碳酸血症的大潮气量被认为对发育中的肺特别有害。因此，在这些新生儿中，支气管肺发育不良/慢性肺病的发病率增加。允许性高碳酸血症 (PHC) 是治疗接受辅助通气患者的 5 种策略，其中接受相对较高水平的 PaCO 2 以避免高潮气量、肺过度扩张和低碳酸血症，从而可能减少肺损伤。
Despite important advances in respiratory care, lung injury is still a leading cause of neonatal morbidity in neonates who receive ventilatory support. The duration and intensity of assistE-d ventilation is an important determinant in the development of lung injury, Large tidal volumes used to achieve normocapnia in neonates are considered particularly harmful to the developing lung. Thus in these neonates there is increased incidence of Bronchopulmonary dysplasia/chronic lung <lisease. Permissive Hypercapnia (PHC) is a 5trategy for the management of patients receiving assisted ventilation in which relatively high levels of PaC0 2 are accepted to avoid high tidal volumP-s, pulmonary overdistension and hypocapnia, thus potentially reducing lung injury.