Gene survival and death on the human Y chromosome.
Gene survival and death on the human Y chromosome.
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DOI：
10.1093/molbev/mss267
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发表时间：
2013-04
影响因子：
10.7
通讯作者：
Makova KD
中科院分区：
文献类型：
--
作者：
Wilson Sayres MA;Makova KD
Y chromosomes have long been dismissed as “graveyards of genes,” but there is still much to be learned from the genetic relics of genes that were once functional on the human Y. We identified human X-linked genes whose gametologs have been pseudogenized or completely lost from the Y chromosome and inferred which evolutionary forces may be acting to retain genes on the Y. Although gene loss appears to be largely correlated with the suppression of recombination, we observe that X-linked genes with functional Y homologs evolve under stronger purifying selection and are expressed at higher levels than X-linked genes with nonfunctional Y homologs. Additionally, we support and expand upon the hypothesis that X inactivation is primarily driven by gene loss on the Y. Using linear discriminant analysis, we show that X-inactivation status can successfully classify 90% of X-linked genes into those with functional or nonfunctional Y homologs.
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影响因子：
64.8
作者：
Hughes, Jennifer F.;Skaletsky, Helen;Brown, Laura G.;Pyntikova, Tatyana;Graves, Tina;Fulton, Robert S.;Dugan, Shannon;Ding, Yan;Buhay, Christian J.;Kremitzki, Colin;Wang, Qiaoyan;Shen, Hua;Holder, Michael;Villasana, Donna;Nazareth, Lynne V.;Cree, Andrew;Courtney, Laura;Veizer, Joelle;Kotkiewicz, Holland;Cho, Ting-Jan;Koutseva, Natalia;Rozen, Steve;Muzny, Donna M.;Warren, Wesley C.;Gibbs, Richard A.;Wilson, Richard K.;Page, David C.
通讯作者：
Page, David C.
DOI：
10.1098/rstb.2000.0717
发表时间：
2000-11-29
影响因子：
6.3
作者：
Charlesworth, B;Charlesworth, D
通讯作者：
Charlesworth, D
影响因子：
64.8
作者：
Zhang, Yu;Sturgill, David;Oliver, Brian
通讯作者：
Oliver, Brian
影响因子：
4.5
作者：
Carrel L;Park C;Tyekucheva S;Dunn J;Chiaromonte F;Makova KD
通讯作者：
Makova KD
影响因子：
9.8
作者：
Whibley, Annabel C.;Plagnol, Vincent;Raymond, F. Lucy
通讯作者：
Raymond, F. Lucy