Modernized Low Pressure Carbonylation Methods in Batch and Flow Employing Common Acids as a CO Source
Modernized Low Pressure Carbonylation Methods in Batch and Flow Employing Common Acids as a CO Source
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DOI：
10.1021/ol401092a
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发表时间：
2013-06-07
期刊：
影响因子：
5.2
通讯作者：
Ryu, Ilhyong
中科院分区：
文献类型：
--
作者：
Brancour, Celia;Fukuyama, Takahide;Ryu, Ilhyong
羰基化反应，如 Heck、Sonogashira 和自由基羰基化，均在“两室反应器”中成功进行，其中通过摩根反应（甲酸通过硫酸脱水）异位产生一氧化碳。通过随后在使用“管中管”反应器的微流系统中的应用（其中使用透气的 Teflon AF2400 作为内管），证明了在芳基碘化物的 Heck 氨基羰基化反应中，甲酸/硫酸可以与胺碱（例如三乙胺）同时使用。
Carbonylation reactions, such as Heck, Sonogashira, and radical carbonylations, were successfully carried out in a "two-chamber reactor" where carbon monoxide was produced ex situ by the Morgan reaction (dehydration of formic acid by sulfuric acid). By a subsequent application In a microflow system using a "tube-in-tube" reactor where gas-permeable Teflon AF2400 was used as the inner tube, it is demonstrated that formic acid/sulfuric acid can be employed concomitantly with an amine base such as triethylamine in the Heck aminocarbonylation of aryl iodide.