IMMUNOTHERAPY OF THE NONOBESE DIABETIC MOUSE - TREATMENT WITH AN ANTIBODY TO T-HELPER LYMPHOCYTES
IMMUNOTHERAPY OF THE NONOBESE DIABETIC MOUSE - TREATMENT WITH AN ANTIBODY TO T-HELPER LYMPHOCYTES
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DOI：
10.1126/science.2966437
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发表时间：
1988-04-29
期刊：
影响因子：
56.9
通讯作者：
FATHMAN, CG
中科院分区：
文献类型：
--
作者：
SHIZURU, JA;TAYLOREDWARDS, C;FATHMAN, CG
自发性糖尿病在非肥胖糖尿病小鼠中被阻断，通过治疗与L3 T4决定簇的表面上的辅助性T淋巴细胞的单克隆抗体。用单克隆抗体持续治疗导致与胰岛素产生β-受体破坏相关的淋巴细胞浸润停止。细胞此外，在抗体治疗停止后，小鼠保持血糖正常。这些研究表明，用针对淋巴细胞亚群的单克隆抗体进行免疫治疗不仅可以阻止糖尿病的进展，而且可能在治疗结束后导致疾病的长期逆转。
Spontaneous diabetes mellitus was blocked in nonobese diabetic mice by treatment with a monoclonal antibody against the L3T4 determinant present on the surface of T-helper lymphocytes. Sustained treatment with the monoclonal antibody led to cessation of the lymphocytic infiltration associated with the destruction of the insulin-producing .beta. cells. Moreover, the mice remained normoglycemic after the antibody therapy was stopped. These studies indicate that immunotherapy with monoclonal antibodies to the lymphocyte subset may not only halt the progression of diabetes, but may lead to long-term reversal of the disease after therapy has ended.