Effect of pulmonary venous pressure elevation on vascular resistance and compliance.
Effect of pulmonary venous pressure elevation on vascular resistance and compliance.
复制标题
肺静脉压升高对血管阻力和顺应性的影响。
DOI：
10.1152/ajpheart.1990.258.4.h1164
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Taylor,AE
中科院分区：
文献类型：
--
作者：
Barman,SA;Taylor,AE
在控制血管张力时和用组胺增加血管张力后测定肺静脉压升高对犬肺循环中阻力和顺应性的纵向分布的影响。采用动脉、静脉和双闭塞技术对离体狗肺进行恒流灌注血液。当肺静脉压以连续 5 cmH2O 增量升至 30 cmH2O 高于等重静脉压条件时，研究了两种血管张力条件下的大血管和小血管阻力和顺应性。这项研究的结果表明，肺静脉压升高至等重静脉压以上 20 cmH2O，可通过降低小静脉阻力和大静脉阻力来显着降低总血管阻力，这种效果在组胺处理的肺部中更为明显。此外，在控制血管张力的情况下，在此压力范围内中室顺应性和总顺应性均大大降低。组胺治疗显着降低了低静脉压升高之前和期间的大血管和中室顺应性。当静脉压在组胺存在的情况下升高至比对照流出压至少高 25 cmH2O 时，中室顺应性再次显着降低。
The effect of pulmonary venous pressure elevation on the longitudinal distribution of resistance and compliance in the canine pulmonary circulation was determined at control vascular tone and after vascular tone was increased with histamine. The arterial, venous, and double-occlusion techniques were used in isolated dog lungs blood perfused at constant flow. The large and small blood vessel resistances and compliances were studied under both vascular tone conditions when pulmonary venous pressure was elevated above isogravimetric venous pressure conditions in successive 5 cmH2O increments up to 30 cmH2O. The results of this study indicate that pulmonary venous pressure elevations to 20 cmH2O above isogravimetric venous pressure significantly decrease total vascular resistance by reducing both the small and large vein resistances, an effect which is more pronounced in the histamine-treated lungs. Also, under control vascular tone, both the middle compartment compliance and total compliance were greatly decreased over this pressure range. Histamine treatment significantly reduced both the large vessel and middle compartment compliances before and during low venous pressure elevation. When venous pressure was then raised to at least 25 cmH2O above control outflow pressure with histamine present, the middle compartment compliance was again significantly decreased.