Central somatostatin prevents vagal efferent nerve excitation produced by TRH but not by 2-deoxy-D-glucose.
Central somatostatin prevents vagal efferent nerve excitation produced by TRH but not by 2-deoxy-D-glucose.
复制标题
中枢生长抑素可阻止 TRH 产生的迷走神经传出神经兴奋，但不能阻止 2-脱氧-D-葡萄糖产生的迷走神经传出神经兴奋。
DOI：
10.1152/ajpgi.1997.272.2.g351
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
K. Miyasaka
中科院分区：
文献类型：
--
作者：
M. Masuda;S. Kanai;K. Miyasaka
侧脑室注射促甲状腺激素释放激素（TRH）和静脉注射2-脱氧-D-葡萄糖（2-DG）均可通过迷走神经兴奋刺激胰腺外分泌。我们研究了中枢给予生长抑素是否会抑制清醒大鼠迷走神经传出神经兴奋刺激的胰腺外分泌。为动物准备分别引流胆汁和胰液的套管以及十二指肠套管、脑室套管和右颈静脉套管。侧脑室注射生长抑素（0.4或4 nmol）可明显抑制TRH（50或500 pmol）诱导的胰腺分泌，并呈剂量依赖性。静脉注射生长抑素对TRH刺激的胰腺分泌无影响。另一方面，中枢注射生长抑素不影响2-DG（75 mg/kg）诱导的胰腺分泌或基础分泌。这些结果表明，TRH和2-DG刺激迷走神经传出神经通过不同的机制和中枢生长抑素选择性抑制兴奋的肽能（TRH）刺激诱导的迷走神经。
Thyrotropin-releasing hormone (TRH) administered intracerebroventricularly and intravenous injection of 2-deoxy-D-glucose (2-DG) stimulate pancreatic exocrine secretion via vagal efferent nerve excitation. We examined whether centrally administered somatostatin would inhibit pancreatic exocrine secretion that was stimulated by vagal efferent nerve excitation in conscious rats. The animals were prepared with cannulas draining bile and pancreatic juice separately and with a duodenal cannula, a cerebroventricular cannula, and a right jugular vein cannula. Intracerebroventricular injection of somatostatin (0.4 or 4 nmol) significantly inhibited pancreatic secretion induced by TRH (50 or 500 pmol) in a dose-dependent manner. Intravenous injection of somatostatin had no effect on pancreatic secretion stimulated by TRH. On the other hand, somatostatin injected centrally did not affect pancreatic secretion induced by 2-DG (75 mg/kg) or basal secretion. These results suggest that TRH and 2-DG stimulate vagal efferent nerves via distinct mechanisms and that central somatostatin selectively inhibits excitation of the vagus induced by peptidergic (TRH) stimulation.