Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase
Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase
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DOI：
10.1124/mol.107.034447
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发表时间：
2007-07-01
影响因子：
3.6
通讯作者：
Ha, Joohun
中科院分区：
文献类型：
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作者：
Kim, Eun Ju;Jung, Seung-Nam;Ha, Joohun
代谢紊乱，包括 2 型糖尿病和肥胖症，是工业化国家的主要健康风险。 AMP 激活蛋白激酶 (AMPK) 作为治疗代谢综合征的新型治疗靶点已成为备受关注的焦点，因为 AMPK 已被证明至少部分地介导许多对这些疾病产生有益作用的生理和药理学因素的作用。因此，激活 AMPK 途径的化合物的鉴定将对此类综合征的治疗和管理做出重大贡献。为了实现这一目标，我们筛选了多种天然存在的化合物，并确定了一种化合物，即隐丹参酮，作为一种新型 AMPK 途径激活剂。隐丹参酮最初是从丹参的干燥根中分离出来的，丹参是一种在亚洲医学中广泛使用的草药，已知对循环系统产生有益作用。在本研究中，我们首次描述了隐丹参酮在体外和体内的有效抗糖尿病和抗肥胖作用。我们的研究结果表明，AMPK 通路的激活可能有助于开发治疗 2 型糖尿病和肥胖等代谢性疾病的新治疗方法。
Metabolic disorders, including type 2 diabetes and obesity, represent major health risks in industrialized countries. AMP-activated protein kinase (AMPK) has become the focus of a great deal of attention as a novel therapeutic target for the treatment of metabolic syndromes, because AMPK has been demonstrated to mediate, at least in part, the effects of a number of physiological and pharmacological factors that exert beneficial effects on these disorders. Thus, the identification of a compound that activates the AMPK pathway would contribute significantly to the treatment and management of such syndromes. In service of this goal, we have screened a variety of naturally occurring compounds and have identified one compound, pound, cryptotanshinone, as a novel AMPK pathway activator. Cryptotanshinone was originally isolated from the dried roots of Salvia militorrhiza, an herb that is used extensively in Asian medicine and that is known to exert beneficial effects on the circulatory system. For the first time, in the present study, we have described the potent antidiabetic and antiobesity effects of cryptotanshinone, both in vitro and in vivo. Our findings suggest that the activation of the AMPK pathway might contribute to the development of novel therapeutic approaches for the treatment of metabolic disorders such as type 2 diabetes and obesity.