The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5.
The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5.
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人类转醛醇酶基因 (TALDO1) 位于 11 号染色体上的 p15.4-p15.5。
DOI：
10.1006/geno.1997.4932
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Perl,A
中科院分区：
文献类型：
--
作者：
Banki,K;Eddy,RL;Shows,TB;Halladay,DL;Bullrich,F;Croce,CM;Jurecic,V;Baldini,A;Perl,A
Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway, which is responsible for generation of reducing equivalents to protect cellular integrity from reactive oxygen intermediates. While exons 2 and 3 are highly repetitive, the complete TAL-H gene is mapped to a single genomic locus (TALDO12) by several independent approaches. Southern blot hybridization of a 827-bp 3′EcoRI fragment of the TAL-H cDNA to human–mouse somatic cell hybrid DNA localized TALDO1 to the p13 → pter region of chromosome 11. Fluorescencein situhybridization with a 15-kb genomic fragment harboring exons 1 and 2 mapped TALDO1 to 11p15.4–p15.5. A truncated and mutated segment of TAL-H exon 5 terminating with a poly(A) tail was identified in a pseudogene locus (TALDOP1) on chromosome 1. Reverse transcriptase–PCR studies of human–mouse somatic cell hybrids revealed the presence of the functional TAL-H gene on chromosome 11 and its absence on human chromosome 1. Mapping of radiation hybrids placed TALDO1 between markers WI-1421 and D11S922 on 11p15.
