Clinical features and outcomes in patients with extraskeletal Ewing sarcoma.
Clinical features and outcomes in patients with extraskeletal Ewing sarcoma.
复制标题
DOI：
10.1002/cncr.25840
复制
发表时间：
2011-07-01
期刊：
影响因子：
6.2
通讯作者：
DuBois, Steven G.
中科院分区：
文献类型：
--
作者：
Applebaum, Mark A.;Worch, Jennifer;Matthay, Katherine K.;Goldsby, Robert;Neuhaus, John;West, Daniel C.;DuBois, Steven G.
尤文肉瘤可以发生在骨或软组织部位。我们试图研究骨骼尤文肉瘤和皮肤外尤文肉瘤（EES）的患者特征、治疗策略和结局是否不同。根据骨源性（n=1519）与骨外源性（n=683），对1973年至2007年美国SEER数据库中报告的年龄< 40岁的尤文肉瘤或外周原始神经外胚层肿瘤（PNET）患者进行评价。使用Fisher精确检验比较患者特征。采用Kaplan-Meier方法估计总生存期，并采用对数秩检验和考克斯模型进行比较。与骨骼肿瘤患者相比，EES患者的平均年龄更高（19.5 vs. 16.3岁; p < 0.001），男性（53.4% vs. 63.3%; p < 0.001）或白色（84.8% vs. 92.5%; p < 0.001）的可能性更低。骨外肿瘤更可能发生在轴位（72.9% vs. 54.2%; p = 0.001），尽管不太可能发生在骨盆（19.8% vs. 26.6%; p < 0.001）。转移状态或肿瘤大小在各组之间没有差异。局部EES的5年总生存率上级优于局部骨骼肿瘤（69.7% vs. 62.6%; p = 0.02）。与局限性EES相比，局限性骨骼肿瘤患者在初次诊断后24个月后死亡的风险比为2.36（95% CI 1.61-3.44）。与骨骼尤文肉瘤患者相比，EES患者的患者特征和结局不同。这些发现可能对患者护理具有重要意义。
Ewing sarcoma can arise in either bone or soft tissue locations. We sought to investigate if patient characteristics, treatment strategies, and outcomes differ between skeletal Ewing sarcoma and extraskeletal Ewing sarcoma (EES). Patients < 40 years of age with Ewing sarcoma or peripheral primitive neuroectodermal tumor (PNET) reported to the US SEER database from 1973 to 2007 were evaluated based on skeletal (n=1519) vs. extraskeletal (n=683) site of origin. Patient characteristics were compared using Fisher exact tests. Overall survival was estimated by Kaplan-Meier methods and compared using log-rank tests and Cox models. Patients with EES had a higher mean age (19.5 vs. 16.3 years; p < 0.001) and were less likely to be male (53.4% vs. 63.3%; p < 0.001) or white (84.8% vs. 92.5%; p < 0.001) compared to patients with skeletal tumors. Extraskeletal tumors were more likely to arise in axial locations (72.9% vs. 54.2%; p = 0.001), though less likely to arise specifically in the pelvis (19.8% vs. 26.6%; p < 0.001). Metastatic status or tumor size did not differ by group. Five-year overall survival was superior for localized EES compared to localized skeletal tumors (69.7% vs. 62.6%; p = 0.02). The hazard ratio for death in patients with localized skeletal tumors compared to localized EES was 2.36 (95% CI 1.61-3.44) beyond 24 months from initial diagnosis. Patient characteristics and outcomes differ among patients with EES compared to patients with skeletal Ewing sarcoma. These findings may have important implications for patient care.
登录
查看更多内容
影响因子：
50.5
作者：
Hense, HW;Ahrens, S;Jürgens, H
通讯作者：
Jürgens, H
影响因子：
6.2
作者：
Lee, Joe;Hoang, Bang H.;Zell, Jason A.
通讯作者：
Zell, Jason A.
影响因子：
--
作者：
SORENSEN, PHB;LIU, XF;TRICHE, TJ
通讯作者：
TRICHE, TJ
影响因子：
3.4
作者：
El Weshi, A.;Allam, A.;Memon, M.
通讯作者：
Memon, M.
影响因子：
45.3
作者：
Granowetter, Linda;Womer, Richard;Grier, Holcombe E.
通讯作者：
Grier, Holcombe E.