Time trends and heterogeneity in the disease burden of glaucoma, 1990-2017: a global analysis
Time trends and heterogeneity in the disease burden of glaucoma, 1990-2017: a global analysis
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1990-2017 年青光眼疾病负担的时间趋势和异质性：全球分析。
DOI：
10.7189/jogh.09.020436
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发表时间：
2019-12-01
影响因子：
7.2
通讯作者：
Lan, Yuqing
中科院分区：
文献类型：
--
作者：
Zhang, Yichi;Jin, Guangming;Lan, Yuqing
背景通过残疾调整生命年（DALY）来评估青光眼的疾病负担，并评估危险因素对青光眼DALY的贡献。方法从全球疾病负担研究2017数据库中获得全球、地区和国家青光眼DALY数量、比率和年龄标准化比率。人类发展指数、经不平等调整的人类发展指数、社会人口指数和其他国家一级的数据来自国际开放数据库。回归分析用于评估年龄标准化DALY率与变量之间的相关性。结果从1990年到2017年，青光眼导致的全球DALY增加了81%，在调整年龄和人口规模后，在过去的二十年中下降了10%。男性的年龄标准化DALY率较高（P < 0.001）。低收入或低SDI国家的年龄标准化DALY率较高（P < 0.001）。2017年国家级年龄标准化DALY率与HDI、SDI、国家级年龄标准化白内障患病率、白内障手术率（CRS）、医生比率和不平等调整后HDI呈负相关。多元逐步回归分析显示，在调整其他混杂因素后，HDI、CRS和不平等调整HDI与2017年全国年龄标准化DALY率呈显著负相关（P <0. 001）。这些发现可以为政策制定者提供信息，并可以作为减轻青光眼疾病负担的动力。
Background To evaluate the disease burden of glaucoma in terms of disability-adjusted life years (DALY) and assess the contribution of risk factors to DALY due to glaucoma.Methods Global, regional, and country DALY number, rate, and age-standardized rates of glaucoma were obtained from the Global Burden of Disease Study 2017 database. The Human Development Index (HDI), Inequality-Adjusted HDI, Socio-Demographic Index (SDI), and other country-level data were derived from international open databases. Regression analysis was used to assess the correlations between the age-standardized DALY rate and the variables.Results The global DALY due to glaucoma increased by 81% from 1990 to 2017 and decreased by 10% over the last two decades after adjusting for age and population size. Males had higher age-standardized DALY rates (P < 0.001). The age-standardized DALY rate was higher in countries with lower income or lower SDI (P < 0.001). The country-level age-standardized DALY rates in 2017 were negatively associated with HDI, SDI, country-level age-standardized prevalence rates of cataracts, cataract surgery rates (CRS), physician rates, and Inequality-Adjusted HDI. Stepwise multiple regressions showed that HDI, CRS, and Inequality-Adjusted HDI were significantly negatively associated with the country-level age-standardized DALY rate in 2017 after adjusting for other confounding factors (P < 0.001).Conclusions Higher education, higher CRS, and diminishing the inequality in resource distribution may help reduce the disease burden of glaucoma. These findings can provide information for policymakers and could serve as an impetus for efforts toward alleviating the disease burden of glaucoma.