Use of functional imaging in parkinsonism and dementia
Use of functional imaging in parkinsonism and dementia
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DOI：
10.1002/mds.10568
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发表时间：
2003-01-01
影响因子：
8.6
通讯作者：
O'Brien, JT
中科院分区：
文献类型：
--
作者：
Burn, DJ;O'Brien, JT
包括痴呆症在内的神经精神症状经常与帕金森病共存，并可能导致诊断混乱和管理问题。功能成像研究包括单光子发射计算机断层扫描(SPECT)、正电子发射断层扫描(PET)、质子磁共振波谱、扩散张量成像和功能磁共振成像。本文从临床医生的角度阐述了这些技术的实用性，重点介绍了帕金森氏症和认知障碍、帕金森氏病伴痴呆症、路易体痴呆症和阿尔茨海默病的最常见原因。这些技术在准确和早期诊断、监测疾病进展和建立关键临床特征的病理生理学基础方面的潜力和局限性被考虑在内。能够标记蛋白质聚集体(例如，β-淀粉样蛋白)的SPECT和PET相机的新探针的开发将为病理生理过程的空间和时间模式提供令人兴奋的新见解。具有临床病理相关性的纵向研究代表了全面评估功能成像技术的“黄金标准”。(C)2003年行动障碍会。
Neuropsychiatric symptoms, including dementia, frequently coexist with parkinsonian disorders and may cause diagnostic confusion as well as management problems. Functional imaging studies include single photon emission computerised tomography (SPECT), positron emission tomography (PET), proton magnetic resonance spectroscopy, diffusion tensor imaging, and functional magnetic resonance imaging. This review addresses the utility of these techniques, from the clinician's perspective, focusing on the most common causes of parkinsonism and cognitive impairment, Parkinson's disease with dementia, dementia with Lewy bodies, and Alzheimer's disease. The potential and limitations of these techniques for accurate and early diagnosis, monitoring disease progression, and establishing the pathophysiological basis underlying key clinical features are considered. The development of new probes for SPECT and PET cameras capable of labeling protein aggregates (e.g., beta-amyloid) will offer exciting new insights into the spatial and temporal pattern of pathophysiological processes. Longitudinal studies with clinicopathological correlation represent the "gold standard" for fully evaluating functional imaging techniques. (C) 2003 Movement Disorder Society.