Shen (Kidney)-tonifying principle for primary osteoporosis: to treat both the disease and the Chinese medicine syndrome
Shen (Kidney)-tonifying principle for primary osteoporosis: to treat both the disease and the Chinese medicine syndrome
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DOI：
10.1007/s11655-015-2306-z
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发表时间：
2015-09-01
影响因子：
2.9
通讯作者：
Wang Yong-jun
中科院分区：
文献类型：
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作者：
Shu Bing;Shi Qi;Wang Yong-jun
原发性骨质疏松症（POP）是老年人最常见的疾病之一，导致骨折风险高和生活质量差。除了骨量的病理改变外，大多数POP患者还患有肾精亏虚的中医证候。神精与骨有密切关系。肾精亏虚在POP的发生发展中起重要作用，中医证候与西医危险因素相结合可以更好地诊断POP。 POP的治疗应以增加骨量和缓解肾精虚证为目标。临床研究证实，用补肾中药治疗POP患者，可以增加POP患者的骨量，缓解CM综合征。基础研究阐明了补神药在动物模型中增加骨量的机制。神通化草药缓解 CM 综合征的机制仍在研究中。
Primary osteoporosis (POP) is one of the most common diseases in the elderly people resulting in high risk of fracture and poor quality of life. In addition to the pathological changes in bone mass, most of the POP patients also suffer from Chinese medicine (CM) syndromes of Shen (Kidney) essence deficiency. Shen essences are highly related to bone. Shen essence deficiency plays an important part in the development of POP and a better diagnosis of POP could be made by combining CM syndromes with Western medicine risk factors. Treatments of POP should aim at both increasing the bone mass and relieving the syndromes of Shen essence deficiency. Clinical study confirmed that treating POP patients with Shen-tonifying herbs could increase the bone mass and relieve the CM syndromes of POP patients. Basic researches clarified the mechanism by which Shen-tonifying herbs increased bone mass in animal models. The mechanisms by which Shentonifying herbs relieve the CM syndromes are still in investigation.