Bacteria mimics bearing carbohydrates, oligodeoxynucleotides and designed shapes
Bacteria mimics bearing carbohydrates, oligodeoxynucleotides and designed shapes
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细菌模仿碳水化合物、寡脱氧核苷酸和设计的形状
DOI：
10.1039/d0cc02239j
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发表时间：
2020
影响因子：
4.9
通讯作者：
Chen Gaojian
中科院分区：
文献类型：
--
作者：
Hu Jun;Gu Yan;Liu Mengjie;Zhang Weidong;Chen Hong;Chen Gaojian
我们利用一种简单而温和的策略，通过基于多巴胺聚合物的纳米颗粒制造和基于DNA的多价相互作用来制造具有碳水化合物、寡脱氧核苷酸和设计形状的细菌模拟物（“芽孢杆菌”和“球菌”）。这些具有TLR和CLR靶向能力的细菌模拟物被证明表现出增强的免疫刺激效率。
We utilize a facile and gentle strategy to fabricate bacteria mimics (“bacillus” and “coccus”) endowed with carbohydrates, oligodeoxynucleotides and designed shapes via dopamine-polymer based nanoparticle fabrication and DNA-based multivalent interactions. These bacteria mimics with TLR- and CLR-targeted capabilities are demonstrated to exhibit enhanced immune stimulating efficiency.