Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis
Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis
复制标题
DOI：
10.1016/j.ijid.2017.12.022
复制
发表时间：
2018-03-01
影响因子：
8.4
通讯作者：
Kubota, Ryuji
中科院分区：
文献类型：
--
作者：
Gao, Hongzhi;Ye, Xiang;Kubota, Ryuji
本文报告1例人类嗜T淋巴细胞病毒1型（HTLV-1）相关性脊髓病/热带痉挛性下肢轻瘫（HAM/TSP）患者。由于未研究抗HTLV-1抗体的存在，该患者的HAM/TSP诊断延迟了4年。磁共振成像显示多个点状病变的颈脊髓，可能反映了病理变化称为血管周围淋巴细胞浸润的脊髓。由于这是中国首例HAM/TSP患者的病例报告，因此建议即使在HTLV-1非流行地区，也应考虑对痉挛性下肢轻瘫患者进行HTLV-1血清学检测。(C)2017作者（S）由Elsevier Ltd代表国际传染病学会出版。
The case of a Chinese patient with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), who showed typical neurological symptoms of the disease, is reported here. Since the presence of anti-HTLV-1 antibody was not investigated, this patient's diagnosis of HAM/TSP was delayed for 4 years. Magnetic resonance imaging revealed multiple spotty lesions in the cervical spinal cord, probably reflecting pathological changes known as perivascular lymphocytic infiltrations of the spinal cord. As this is the first case report of a HAM/TSP patient in China, it is suggested that serological testing for HTLV-1 should be considered in patients with spastic paraparesis even in areas that are non-endemic for HTLV-1. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.