Development and function of the midbrain dopamine system: what we know and what we need to.
Development and function of the midbrain dopamine system: what we know and what we need to.
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中脑多巴胺系统的开发和功能：我们知道和需要什么。
DOI：
10.1111/gbb.12257
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Roesch MR
中科院分区：
文献类型：
--
作者：
Bissonette GB;Roesch MR
在过去的二十年里，我们对中脑多巴胺系统的起源和发展的理解发生了爆炸。这项工作的大部分集中在与运动障碍（如帕金森病）发病相关的多巴胺神经元发育方面，目的是希望延迟，预防或修复症状。虽然中脑多巴胺变性是治疗和研究的主要焦点，但许多其他人类疾病受到异常多巴胺的影响，包括药物成瘾，自闭症和精神分裂症。了解多巴胺神经元个体发育以及多巴胺连接和电路如何发展，可能会为我们提供对其他多巴胺相关疾病研究的潜在重要途径的关键见解。这篇综述将提供一个简要概述的主要分子和遗传球员在整个中脑多巴胺神经元的发展和我们所知道的行为和疾病相关的影响与扰动中脑多巴胺神经元的发展。我们打算结合联合收割机的神经科学的两个广泛领域的知识，发展和行为，在解决复杂的认知问题，从发展的角度来看，并确定我们的知识为未来的研究服务，促进神经科学的分支之间的更多讨论的意图。
The past two decades have seen an explosion in our understanding of the origin and development of the midbrain dopamine system. Much of this work has been focused on the aspects of dopamine neuron development related to the onset of movement disorders such as Parkinson’s disease, with the intent of hopefully delaying, preventing or fixing symptoms. While midbrain dopamine degeneration is a major focus for treatment and research, many other human disorders are impacted by abnormal dopamine, including drug addiction, autism and schizophrenia. Understanding dopamine neuron ontogeny and how dopamine connections and circuitry develops may provide us with key insights into potentially important avenues of research for other dopamine-related disorders. This review will provide a brief overview of the major molecular and genetic players throughout the development of midbrain dopamine neurons and what we know about the behavioral- and disease-related implications associated with perturbations to midbrain dopamine neuron development. We intend to combine the knowledge of two broad fields of neuroscience, both developmental and behavioral, with the intent on fostering greater discussion between branches of neuroscience in the service of addressing complex cognitive questions from a developmental perspective and identifying important gaps in our knowledge for future study.