Stimulus-responsive polymeric micelles for the light-triggered release of drugs.
Stimulus-responsive polymeric micelles for the light-triggered release of drugs.
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DOI：
10.1016/j.carbpol.2013.12.062
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发表时间：
2014-03
影响因子：
11.2
通讯作者：
Bin Wang;Ke-fu Chen;Rendang Yang;Fei Yang;Jin Liu
中科院分区：
文献类型：
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作者：
Bin Wang;Ke-fu Chen;Rendang Yang;Fei Yang;Jin Liu
以乙基纤维素为原料，与2-溴丙酰溴在室温下直接酰化合成了乙基纤维素大分子引发剂。采用原子转移径向聚合法合成了乙基纤维素-g-聚甲基丙烯酸羟乙酯-g-聚甲基丙烯酸螺吡喃醚三嵌段共聚物（EC-g-PHEMA-g-PSPMA）。共聚物的两亲性结构使其在水溶液中聚集成平均直径为100 nm的球形胶束。由于SPMA单体的存在，胶束表现出光响应性能。在紫外光照射下，PSPMA的疏水侧链变成亲水侧链，使胶束的平均粒径减小。此外，当随后用可见光照射时，胶束的直径可以恢复。对模型药物的载药量和光触发释放曲线进行了研究，结果表明，可以通过改变光波长来控制模型药物的释放行为。
Ethyl cellulose macroinitiator was firstly synthesized by direct acylation of ethyl cellulose with 2-bromopropionyl bromide in a room temperature. And a light-responsive triblock copolymer of ethyl cellulose-g-poly(2-hydroxyethyl methacrylate)-g-poly(spiropyran ether methacrylate) (EC-g-PHEMA-g-PSPMA) was prepared by atom transfer radial polymerization. The amphiphilic structure of the copolymer enabled it to aggregate into spherical micelles in aqueous solution with an average diameter of 100 nm. The micelles exhibited light-responsive performance because of the SPMA monomer. The hydrophobic side chain of PSPMA became hydrophilic under UV light, which decreased the average size of the micelles. Additionally, the diameters of the micelles can be recovered when subsequently irradiated with visible light. The loading and light-triggered release profiles of model drugs were also investigated, and results showed that the release behavior can be controlled by changing the light wavelength.