Chromosomal assignment of a family of human oncogenes.
Chromosomal assignment of a family of human oncogenes.
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人类癌基因家族的染色体分配。
DOI：
10.1073/pnas.80.14.4460
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发表时间：
1983
影响因子：
11.1
通讯作者：
Ruddle,FH
中科院分区：
文献类型：
--
作者：
Ryan,J;Barker,PE;Shimizu,K;Wigler,M;Ruddle,FH
人类转化基因家族，先前显示与病毒致癌基因ras家族共享同源性，映射到三个不同的人类染色体。本研究采用了一种具有良好特征的鼠-人杂交细胞组，并结合Southern印迹法。膀胱癌细胞系T24的转化基因定位于人11号染色体。从肺癌细胞系SK-Calu-1中分离到的致癌基因映射到人类12号染色体上。第三个ras相关基因是从神经母细胞瘤细胞系SK-N-SH中克隆出来的，定位于人类1号染色体。
A family of human transforming genes, previously shown to share homology with the ras family of viral oncogenes, maps to three different human chromosomes. A well-characterized mouse-human hybrid cell panel, combined with Southern blotting, was used in this study. The transforming gene of the T24 bladder carcinoma cell line maps to human chromosome 11. An oncogene isolated from the lung carcinoma cell line SK-Calu-1 maps to human chromosome 12. The third ras-related gene, cloned from SK-N-SH, a neuroblastoma cell line, maps to human chromosome 1.