HERPES-SIMPLEX VIRUS - THE MOST FREQUENTLY ISOLATED PATHOGEN IN THE LUNGS OF PATIENTS WITH SEVERE RESPIRATORY-DISTRESS
HERPES-SIMPLEX VIRUS - THE MOST FREQUENTLY ISOLATED PATHOGEN IN THE LUNGS OF PATIENTS WITH SEVERE RESPIRATORY-DISTRESS
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DOI：
10.3109/00365549209061333
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发表时间：
1992-01-01
影响因子：
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通讯作者：
WIDELL, A
中科院分区：
文献类型：
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作者：
PRELLNER, T;FLAMHOLC, L;WIDELL, A
连续308例严重或复杂性呼吸道感染患者接受了纤维支气管镜检查，以寻找微生物病因。使用受保护的刷拭标本进行细菌培养和支气管肺泡灌洗（BAL）进行病毒分离和细胞学检查。单纯疱疹病毒（HSV）是最常见的病原体，并在37例患者中分离出来。其中20例（54%）有HSV感染的血清学和/或细胞学表现。132名患者需要辅助通气（AV），其中37名患者中有34名（92%）出现单纯疱疹病毒阳性。与不需要AV的患者相比，单纯疱疹病毒的分离与AV显着相关（p < 0.001）。在所有接受AV治疗的患者中，26%的患者HSV分离阳性，并伴有疑似急性下呼吸道感染。单纯疱疹病毒和细菌共感染仅8例（22%）。HSV在烧伤患者中更常见（47%），而其他患者组如艾滋病患者（3%）或其他免疫缺陷患者（9%）。
308 consecutive patients with severe or complicated respiratory tract infections underwent fiber-optic bronchoscopy in the search for a microbiological etiology. Protected brush specimens were used for bacterial cultures and bronchoalveolar lavage (BAL) for virus isolation and cytological examination. Herpes simplex virus (HSV) was the most commonly found pathogen and was isolated in 37 patients. 20 (54%) of them also had serological and/or cytological signs of HSV infection. 132 patients required assisted ventilation (AV) and in this group 34 (92%) of the 37 HSV positive patients were found. Isolation of HSV was significantly (p < 0.001) associated with AV compared to patients not requiring AV. Of all patients treated with AV 26% had positive HSV isolation in conjunction with suspected acute lower respiratory infection. Coinfection with HSV and bacteria occurred in only 8 (22%) patients. HSV was more common in patients with burns (47%) compared to other patient groups such as patients with AIDS (3%) or other immunodeficiencies (9%).