Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting
Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting
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DOI：
10.2463/mrms.mp.2019-0048
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发表时间：
2020-01-01
影响因子：
3
通讯作者：
Sone, Michihiko
中科院分区：
文献类型：
--
作者：
Naganawa, Shinji;Nakane, Toshiki;Sone, Michihiko
目的：据报道，即使在健康受试者中，静脉内给予的钆基造影剂（IV-GBCA）从皮质静脉泄漏到脑脊液（CSF）中，也可以使用高灵敏度脉冲序列（如重T-2加权3D液体衰减反转恢复和3D真实反转恢复（IR））进行检测。本研究的目的是评估MR指纹技术检测IV-GBCA后皮质静脉GBCA渗漏的可行性。材料：14例疑似内淋巴积水（EH）的患者（39-79岁）接受了单次IV-GBCA治疗。在IV-GBCA后4 h获得真实的IR图像以及MR指纹图像。使用MR指纹识别获得T-1和T-2值，并在ROI中进行分析，这些ROI覆盖了强烈的GBCA泄漏和在真实的IR图像上确定的CSF非泄漏区域。真实的IR成像扫描时间为10 min，MR指纹成像扫描时间为41 s。结果：GBCA渗漏区ROI的平均T-1值为2422 ± 261 ms，非渗漏区为3851 ± 235 ms（P < 0.01）。GBCA泄漏区域和非泄漏区域的T-1值之间没有重叠。GBCA渗漏区的平均T-2值为319 ± 90 ms，非渗漏区为670 ± 166 ms（P < 0.01）。结论：应用MR指纹图谱可检测出皮质静脉漏入周围脑脊液的GBCA。
Purpose: It has been reported that leakage of intravenously administered gadolinium-based contrast agents (IV-GBCAs) into the cerebrospinal fluid (CSF) from the cortical veins even in healthy subjects can be detected using a highly sensitive pulse sequence such as heavily T-2-weighted 3D fluid-attenuated inversion recovery and 3D-real inversion recovery (IR). The purpose of this study was to evaluate the feasibility of MR fingerprinting to detect GBCA leakage from the cortical veins after IV-GBCA.Materials: Fourteen patients with suspected endolymphatic hydrops (EH) who received a single dose of IV-GBCA (39-79 years old) were included. The real IR images as well as MR fingerprinting images were obtained at 4 h after IV-GBCA. T-1 and T-2 values were obtained using MR fingerprinting and analyzed in ROIs covering intense GBCA leakage, and non-leakage areas of the CSF as determined on real IR images. The scan time for real IR imaging was 10 min and that for MR fingerprinting was 41 s.Results: The mean T-1 value of the ROI in the area of GBCA leakage was 2422 +/- 261 ms and that in the non-leakage area was 3851 +/- 235 ms (P < 0.01). There was no overlap between the T-1 values in the area of GBCA leakage and those in the non-leakage area. The mean T-2 value in the area of GBCA leakage was 319 +/- 90 ms and that in the non-leakage area was 670 +/- 166 ms (P < 0.01). There was some overlap between the T-2 values in the area of GBCA leakage and those in the non-leakage area.Conclusion: Leaked GBCA from the cortical veins into the surrounding CSF can be detected using MR fingerprinting obtained in