Serum Soluble CD163 Predicts Risk of Type 2 Diabetes in the General Population
Serum Soluble CD163 Predicts Risk of Type 2 Diabetes in the General Population
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DOI：
10.1373/clinchem.2010.154724
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发表时间：
2011-02-01
影响因子：
9.3
通讯作者：
Tybjaerg-Hansen, Anne
中科院分区：
文献类型：
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作者：
Moller, Holger J.;Frikke-Schmidt, Ruth;Tybjaerg-Hansen, Anne
背景技术背景：脂肪组织巨噬细胞的活化伴随低度炎症被认为在2型糖尿病的发展中起核心作用。我们测试了是否一个新的巨噬细胞衍生的生物标志物，可溶性CD 163（CD 163），确定在风险的个人之前，公开disease happened.METHODS：一项前瞻性队列研究的8849名研究参与者从一般人群中，哥本哈根市心脏研究，随访18年的2型糖尿病的发病率。根据年龄和性别校正的血清sCD 163浓度百分位数分类计算疾病风险：0%-33%，34%-66%，67%-90%，91%-95%，96%-100%.Results：共有568名参与者发展为2型糖尿病。累积发病率随着基线sCD 163的增加而增加（趋势P < 0.001），sCD 163与已知的危险因素如身体活动不足、体重指数、C反应蛋白和甘油三酯密切相关（均P < 0.001）。与0%-33%类别相比，34%-66%、67%-90%、91%-95%和96%-100%类别2型糖尿病的多因素校正风险比分别为1.4（95% CI，1.0-1.9）、2.4（1.8-3.2）、3.8（2.6-5.5）和5.2（3.6-7.6）。在50-70岁和>70岁的超重男性中，血清sCD 163浓度在最高5%组中预测2型糖尿病的绝对10年风险为29%和36%，而在最低百分位数组中为7%和8%。女性的相应值分别为19%和24%vs4%和5%.CONCLUSION：sCD 163浓度升高可预测普通人群中2型糖尿病的风险增加，并可用于识别高危超重个体。(C)2010年美国临床化学协会
BACKGROUND: Activation of adipose tissue macrophages with concomitant low-grade inflammation is believed to play a central role in the development of type 2 diabetes. We tested whether a new macrophage-derived biomarker, soluble CD163 (sCD163), identifies at-risk individuals before overt disease has developed.METHODS: A prospective cohort study of 8849 study participants from the general population, the Copenhagen City Heart Study, was followed for 18 years for incidence of type 2 diabetes. Risk of disease was calculated according to age- and sex-adjusted percentile categories of serum sCD163 concentrations: 0%-33%, 34%-66%, 67%-90%, 91%-95%, and 96%-100%.RESULTS: A total of 568 participants developed type 2 diabetes. The cumulative incidence increased with increasing baseline sCD163 (trend P < 0.001), and sCD163 was strongly associated with known risk factors such as physical inactivity, body mass index, C-reactive protein, and triglycerides (all P < 0.001). Multifactorially adjusted hazard ratios for type 2 diabetes were 1.4 (95% CI, 1.0-1.9), 2.4 (1.8-3.2), 3.8 (2.6-5.5), and 5.2 (3.6-7.6) for categories 34%-66%, 67%-90%, 91%-95%, and 96%-100%, respectively, vs the 0%-33% category. In overweight men 50-70 and >70 years of age, serum sCD163 concentrations in the top 5% group predicted an absolute 10-year risk of type 2 diabetes of 29% and 36% vs 7% and 8% in the lowest percentile group. Equivalent values in women were 19% and 24% vs 4% and 5%.CONCLUSIONS: Increased concentrations of sCD163 predict increased risk of type 2 diabetes in the general population and may be useful for identification of high-risk overweight individuals. (C) 2010 American Association for Clinical Chemistry