Two antigenically distinct subtypes of human immunodeficiency virus type 1: viral genotype predicts neutralization serotype.
Two antigenically distinct subtypes of human immunodeficiency virus type 1: viral genotype predicts neutralization serotype.
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人类免疫缺陷病毒 1 型的两种抗原不同亚型：病毒基因型预测中和血清型。
DOI：
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发表时间：
1994
影响因子：
6.4
通讯作者：
D. S. Burke
中科院分区：
文献类型：
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作者：
J. Mascola;Joost Louwagie;F. McCutchan;Carrie L. Fischer;P. Hegerich;Kenneth F. Wagner;Arnold K. Fowler;John G. McNeil;D. S. Burke
通过DNA测序，人类免疫缺陷病毒1型(HIV-1)至少有五种不同的基因亚型。目前的候选疫苗是基于来自北美和欧洲的只代表一个亚型的病毒株。HIV-1的不同基因类型在多大程度上与抗原性可区分的血清型相对应在很大程度上是未知的，可能对疫苗设计至关重要。用来自两个不同基因类型的病毒和血浆进行了交叉神经化研究。根据中和敏感性，来自泰国和美国的10株HIV-1初级分离株被分为与病毒基因相关的两个抗原亚型之一。HIV-1血清型的存在表明，广泛有效的疫苗可能必须包括来自多个亚型的毒株。这些主要的HIV-1分离株的中和结果与实验室毒株的结果有很大不同。未来使用初级分离株和多种基因类型的中和研究对于评估HIV-1抗原多样性可能是重要的。
At least five distinct genetic subtypes (genotypes) of human immunodeficiency virus type 1 (HIV-1) have been identified by DNA sequencing. Current vaccine candidates are based on virus strains from North America and Europe that represent only one subtype. The extent to which distinct genotypes of HIV-1 correspond to antigenically distinguishable serotypes is largely unknown and may be critically important to vaccine design. Cross-neuralization studies were done with viruses and plasma from two different genotypes. Based on neutralization susceptibility, 10 primary HIV-1 isolates from Thailand and the United States were classified into one of two antigenic subtypes that correlated with viral genotype. The existence of serotypes of HIV-1 suggests that a broadly effective vaccine may have to include strains from multiple subtypes. Neutralization of these primary HIV-1 isolates differed substantially from results with laboratory strains. Future neutralization studies using primary isolates and multiple genotypes may be important for assessment of HIV-1 antigenic diversity.