3-D diffusion tensor axonal tracking shows distinct SMA and pre-SMA projections to the human striatum
3-D diffusion tensor axonal tracking shows distinct SMA and pre-SMA projections to the human striatum
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DOI：
10.1093/cercor/bhh091
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发表时间：
2004-12-01
期刊：
影响因子：
3.7
通讯作者：
Kim, DS
中科院分区：
文献类型：
--
作者：
Lehéricy, S;Ducros, M;Kim, DS
对非人类灵长类动物的研究表明，内侧运动前投射到纹状体的特征是一组不同的电路，传递不同类型的信息。本研究利用扩散张量成像（DTI）轴突跟踪技术评估了从辅助运动区（SMA）、前SMA和运动皮层（MC）到人纹状体的解剖投影。8名右撇子志愿者在1.5 T时使用DTI轴突跟踪进行研究。计算连接矩阵，测试每个半球皮层区域（MC、SMA和前SMA）和皮层下区域（后、中、前壳核和尾状核头部）之间的连接。纹状体的前SMA突起位于纹状体的吻侧。SMA和MC同样连接到后壳核和中壳核，而不是连接到前纹状体。这些数据表明，MC和SMA与人类纹状体的感觉运动区有相似的连接，而preSMA与纹状体的吻侧部分有更多的连接，包括联想区。
Studies in non-human primates have shown that medial premotor projections to the striatum are characterized as a set of distinct circuits conveying different type of information. This study assesses the anatomical projections from the supplementary motor area (SMA), pre-SMA and motor cortex (MC) to the human striatum using diffusion tensor imaging (DTI) axonal tracking. Eight right-handed volunteers were studied at 1.5 T using DTI axonal tracking. A connectivity matrix was computed, which tested for connections between cortical areas (MC, SMA and pre-SMA) and subcortical areas (posterior, middle and anterior putamen and the head of the caudate nucleus) in each hemisphere. Pre-SMA projections to the striatum were located rostral to SMA projections to the striatum. The SMA and the MC were similarly connected to the posterior and middle putamen and not to the anterior striatum. These data show that the MC and SMA have connections with similar parts of the sensorimotor compartment of the human striatum, whereas the preSMA sends connections to more rostral parts of the striatum, including the associative compartment.