Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvants
Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvants
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DOI：
10.1007/978-90-481-9078-2_14
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Ireton, Gregory C.
中科院分区：
文献类型：
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作者：
Fox, Christopher B.;Friede, Martin;Ireton, Gregory C.
脂多糖的天然衍生物和合成类似物是哺乳动物免疫系统的有效刺激物。通过开发单磷酰脂A(MPL(R))，获得了保留佐剂活性和降低毒性的结果，该产品已被批准用于几种疫苗产品。正在进行的合成TLR4激动剂的研究和开发可能以更低的成本提供更高的纯度和生物活性。广泛的研究已经阐明了TLR4激动剂的作用机制和结构-功能关系。此外，TLR4激动剂的配方已被证明显著影响诱导的免疫反应的类型和大小。TLR4激动剂是一类很有前途的安全有效疫苗佐剂。
Natural derivatives and synthetic analogues of lipopolysaccharide are potent stimulators of the mammalian immune system. Retained adjuvant activity with reduced toxicity was obtained by the development of monophosphoryl lipid A (MPL(R)), which is approved for use in several vaccine products. Ongoing research and development of synthetic TLR4 agonists may offer increased purity and biological activity with reduced cost. Extensive research has elucidated the mechanism of action of TLR4 agonists and structure-function relationships. Moreover, the formulation of TLR4 agonists has been shown to significantly affect the type and magnitude of elicited immune response. TLR4 agonists comprise a promising class of adjuvants for safe and effective vaccines.