Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and NOS by blocking Akt/NF-κB signal in JB6 cells
Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and NOS by blocking Akt/NF-κB signal in JB6 cells
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DOI：
10.1016/j.canlet.2008.01.022
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发表时间：
2008-06-08
期刊：
影响因子：
9.7
通讯作者：
Cho, Myung-Haing
中科院分区：
文献类型：
--
作者：
Xu, Cheng-Xiong;Jin, Hua;Cho, Myung-Haing
炎症介质在肿瘤发生中起着关键作用，因此，抑制炎症是预防和/或治疗癌症的一种很有前途的策略。本研究旨在探讨从海鞘中提取的硫酸软骨素（CS）对tnf - α诱导的炎症的影响，并阐明CS对JB6细胞炎症因子的调节机制。我们的研究结果表明，CS通过阻断JB6细胞的Akt信号抑制tnf α诱导的NF-kappa B活化和随后的血管细胞粘附分子1和诱导的一氧化氮合酶的表达。我们的结果表明，CS可能在未来发展为一种有效的抗炎药。2008爱思唯尔爱尔兰有限公司版权所有。
Inflammatory mediators are known to play a key role in tumorigenesis, therefore, it is a promising strategy to inhibit the inflammation for cancer prevention and/or treatment. Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells. Our results showed that CS inhibited TNF-alpha-induced NF-kappa B activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells. Our results suggest that CS may be developed as an effective anti-inflammatory agent in the future. (C) 2008 Elsevier Ireland Ltd. All rights reserved.