Dimensional depression severity in women with major depression and post-traumatic stress disorder correlates with fronto-amygdalar hypoconnectivty.
Dimensional depression severity in women with major depression and post-traumatic stress disorder correlates with fronto-amygdalar hypoconnectivty.
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DOI：
10.1038/mp.2015.149
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发表时间：
2016-07
影响因子：
11
通讯作者：
Sheline YI
中科院分区：
文献类型：
--
作者：
Satterthwaite TD;Cook PA;Bruce SE;Conway C;Mikkelsen E;Satchell E;Vandekar SN;Durbin T;Shinohara RT;Sheline YI
抑郁症状在多种精神疾病中很常见，并且是创伤的常见后遗症。抑郁症的维度概念化表明，症状应该与特定神经回路的连续缺陷有关。然而，大多数以前的研究异常的功能连接通常集中在一个单一的诊断类别，使用假设驱动的种子为基础的分析。在这里，使用来自三个诊断组（健康对照组，n = 17;重度抑郁症，n = 38;和创伤后应激障碍，n = 50）的105名成年女性参与者的样本，我们使用数据驱动的分析（基于多变量距离的矩阵回归）来检查静息状态功能障碍与诊断类别中抑郁症状严重程度之间的维度关系。这项连接组范围的分析确定了与双侧杏仁核抑郁严重程度相关的连接障碍病灶。使用受试者特定的杏仁核分割的后续种子分析显示，抑郁症的严重程度与包括双侧背外侧前额叶皮层、前扣带回和前额叶在内的区域网络中的杏仁核-额叶连接不足相关。相比之下，焦虑与杏仁核和腹内侧前额叶皮层之间的连通性升高有关。总之，这些结果强调了杏仁核在抑郁症状的病理生理学中的中心地位，并表明杏仁核-额叶连接障碍的可分离模式是临床诊断类别中的关键神经生物学特征。
Depressive symptoms are common in multiple psychiatric disorders and are frequent sequelae of trauma. A dimensional conceptualization of depression suggests that symptoms should be associated with a continuum of deficits in specific neural circuits. However, most prior investigations of abnormalities in functional connectivity have typically focused on a single diagnostic category using hypothesis-driven seed-based analyses. Here, using a sample of 105 adult female participants from three diagnostic groups (healthy controls, n = 17; major depression, n = 38; and post-traumatic stress disorder, n = 50), we examine the dimensional relationship between resting-state functional dysconnectivity and severity of depressive symptoms across diagnostic categories using a data-driven analysis (multivariate distance-based matrix regression). This connectome-wide analysis identified foci of dysconnectivity associated with depression severity in the bilateral amygdala. Follow-up seed analyses using subject-specific amygdala segmentations revealed that depression severity was associated with amygdalo-frontal hypo-connectivity in a network of regions including bilateral dorsolateral prefrontal cortex, anterior cingulate and anterior insula. In contrast, anxiety was associated with elevated connectivity between the amygdala and the ventromedial prefrontal cortex. Taken together, these results emphasize the centrality of the amygdala in the pathophysiology of depressive symptoms, and suggest that dissociable patterns of amygdalo-frontal dysconnectivity are a critical neurobiological feature across clinical diagnostic categories.