Excitotoxic lesions of the gustatory thalamus eliminate consummatory but not instrumental successive negative contrast in rats.
Excitotoxic lesions of the gustatory thalamus eliminate consummatory but not instrumental successive negative contrast in rats.
复制标题
味觉丘脑的兴奋性毒性损伤消除了大鼠的完成性而非工具性连续负对比。
DOI：
10.1016/j.bbr.2006.01.026
复制
发表时间：
2006
影响因子：
2.7
通讯作者：
Reilly,Steve
中科院分区：
文献类型：
--
作者：
Sastre,Aristides;Reilly,Steve
味觉丘脑（GT）的损伤防止会话间对比效应的发生（即，预期性消极对比和完成性连续性消极对比[cSNC]）。这些赤字是由于奖励比较机制的中断，该机制计算当前奖励相对于预期奖励的价值。仪器连续负对比（iSNC），这发生在一个令人惊讶的减少幅度的固体食物奖励，也切断了检测之间的差距的预期和实际奖励的价值。本研究检查了GT的神经毒性病变是否可以防止iSNC的发生，就像它们消除cSNC一样。在实验1中，GT损伤和神经系统完好的大鼠用10个食物颗粒训练并转移到一个食物颗粒显示出显著的iSNC效应。在实验2中，当从1.0M蔗糖转换为0.15%糖精钠时，相同的GT损伤大鼠未能显示cSNC。所获得的结果模式表明，具有不同神经基质的单独奖励比较机制是cSNC和iSNC表达的基础。
Lesions of the gustatory thalamus (GT) prevent the occurrence of between-session contrast effects (i.e., anticipatory negative contrast and consummatory successive negative contrast [cSNC]) involving liquid rewards. These deficits are attributed to a disruption of the reward comparison mechanism that computes the value of the current reward relative to the expected reward. Instrumental successive negative contrast (iSNC), which occurs following a surprising reduction in the magnitude of a solid food reward, is also keyed off the detection of a disparity between the value of the expected and actual rewards. The present study examined whether neurotoxic lesions of the GT prevent the occurrence of iSNC just as they abolish cSNC. In Experiment 1, both GT-lesioned and neurologically intact rats trained with 10 food pellets and shifted to one food pellet showed a significant iSNC effect. In Experiment 2, the same GT-lesioned rats failed to show cSNC when shifted from 1.0M sucrose to 0.15% sodium saccharin. The obtained pattern of results suggests that separate reward comparison mechanisms with different neural substrates underlie expression of cSNC and iSNC.