Dietary intake of folate, other B vitamins, and ω-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults
Dietary intake of folate, other B vitamins, and ω-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults
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DOI：
10.1016/j.nut.2007.10.013
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发表时间：
2008-02-01
期刊：
影响因子：
4.4
通讯作者：
Mishima, Norio
中科院分区：
文献类型：
--
作者：
Murakami, Kentaro;Mizoue, Tetsuya;Mishima, Norio
目的：虽然饮食叶酸和ω-3多不饱和脂肪酸（PUFA）对抑郁症的有利影响是从西方国家的流行病学研究中提出的，但缺乏来自非西方人群的证据。我们研究了叶酸，其他B族维生素，和w-3多不饱和脂肪酸和抑郁症状在日本adultes.Methods的摄入量之间的横截面关联：受试者是309名日本男性和208名日本女性21-67岁。饮食摄入量进行了评估与验证，简短，自我管理的饮食史问卷。当受试者的流行病学研究中心抑郁量表评分>= 16时，抑郁症状被定义为存在。调整年龄，身体质量指数，工作地点，婚姻状况，职业体力活动，休闲时间体力活动，目前吸烟，目前饮酒，和工作stressscores.Results：抑郁症状的患病率为36%的男性和37%的女性。叶酸摄入量与男性的抑郁症状呈显著的负相关和线性相关，但与女性无关。在叶酸摄入量的第一、第二、第三和第四四个四分位数中，男性抑郁症状的多变量比值比（95%置信区间）分别为1.00（参考）、0.78（参考）、0.79（参考）和0.79（参考）。（0.381-1.63）、0.57（0.27-1.18）和0.50（0.23-1.06）（趋势P = 0.045）。没有统计学显着的线性关联，观察到摄入核黄素，吡哆醇，钴胺素，总ω-3多不饱和脂肪酸，α-亚麻酸，二十碳五烯酸，或二十二碳六烯酸在任一sex.Conclusion：较高的膳食摄入量叶酸与抑郁症状的患病率较低的日本男性，但不是女性。(c)2008年爱思唯尔公司All rights reserved.
Objective: Although a favorable effect of dietary folate and omega-3 polyunsaturated fatty acids (PUFAs) on depression is suggested from epidemiologic studies in Western countries, evidence from non-Western populations is lacking. We examined cross-sectional associations between the intake of folate, other B vitamins, and w-3 PUFAs and depressive symptoms in Japanese adults.Methods: Subjects were 309 Japanese men and 208 Japanese women 21-67 y of age. Dietary intake was assessed with a validated, brief, self-administered diet history questionnaire. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression scale score >= 16. Adjustment was made for age, body mass index, work place, marital status, occupational physical activity, leisure-time physical activity, current smoking, current alcohol drinking, and job stress score.Results: The prevalences of depressive symptoms were 36% for men and 37% for women. Folate intake showed a statistically significant, inverse, and linear association with depressive symptoms in men but not in women. The multivariate odds ratios (95% confidence intervals) for depressive symptoms for men in the first, second, third, and fourth quartiles of folate intake were 1.00 (reference), 0.78.(0.381-1.63) 0.57 (0.27-1.18), and 0.50 (0.23-1.06), respectively (P for trend = 0.045). No statistically significant linear association was observed for the intake of riboflavin, pyridoxine, cobalamin, total omega-3 PUFAs, alpha-linolenic acid, eicosapentacnoic acid, or docosahexaenoic acid in either sex.Conclusion: Higher dietary intake of folate was associated with a lower prevalence of depressive symptoms in Japanese men but not women. (c) 2008 Elsevier Inc. All rights reserved.